Publications by authors named "M Harlow"
Article Synopsis
- Biosecurity practices are essential for reducing disease outbreaks in the pork industry and protecting against foreign animal diseases (FADs).
- The article summarizes data from over 12,000 surveyed sites as part of the United States Swine Health Improvement Plan (US SHIP), highlighting the variety of biosecurity measures in place, such as Secure Pork Supply plans, outdoor access, and visitor protocols.
- As the industry adapts to FAD threats, the findings from this study will help stakeholders enhance biosecurity and ensure the sustainability of the swine sector amid ongoing challenges.
Background: Adequate illumination of the larynx is needed during laryngoscopy to facilitate tracheal intubation. The International Organization for Standardization (ISO) has established a minimum light intensity for direct laryngoscopy (DL) of over 500 lux for at least ten minutes, but no such standard exists for Macintosh geometry videolaryngoscope (Mac-VL) blades, which allow for both direct or indirect (videoscopic) viewing of the larynx. Using in situ bench and in vitro testing in a human cadaver, we determined illumination and luminance values delivered by various Mac-VLs and compared these with published minimum lighting benchmarks as well as a reference direct laryngoscope.
View Article and Find Full Text PDFAlthough activating mutations of the anaplastic lymphoma kinase (ALK) membrane receptor occur in ∼10% of neuroblastoma (NB) tumors, the role of the wild-type (WT) receptor, which is aberrantly expressed in most non-mutated cases, is unclear. Both WT and mutant proteins undergo extracellular domain (ECD) cleavage. Here, we map the cleavage site to Asn654-Leu655 and demonstrate that cleavage inhibition of WT ALK significantly impedes NB cell migration with subsequent prolongation of survival in mouse models.
View Article and Find Full Text PDFArticle Synopsis
- Neurons in the spinal cord can adapt behavior based on environmental stimuli, as seen in rats that learned to protect a hind leg from electrical shocks even after spinal cord injury.
- Blocking spinal neuron activity or disconnecting the sciatic nerve stopped the rats from learning, indicating that spinal neurons are essential for learning, but not for maintaining learned behaviors.
- Training enhances muscle response at the neuromuscular junction by increasing the number of acetylcholine receptors and strengthening connections, with glutamate signaling playing a role in this plasticity.
Background: Despite the recognised benefits of sport, participation is often reported to be low for youth with intellectual disability (ID). The current study was the first to longitudinally examine sport retention in this population, a critical aspect of ensuring participation.
Methods: Study participants were parents/caregivers of athletes with ID involved in community Special Olympics (SO), 11-22 years of age (N = 345).