Publications by authors named "M Hanif Pathan"
Objective: The choice of a stable reference gene plays a crucial role in gene expression analysis. In most cases, the choice of housekeeping gene (HKG) is quite random. However, the expression of HKGs varies under different experimental conditions and in different tissues.
View Article and Find Full Text PDFHigh-altitude regions pose distinctive challenges for cardiovascular health because of decreased oxygen levels, reduced barometric pressure, and colder temperatures. Approximately 82 million people live above 2400 meters, while over 100 million people visit these heights annually. Individuals ascending rapidly or those with pre-existing cardiovascular conditions are particularly vulnerable to altitude-related illnesses, including Acute Mountain Sickness (AMS) and Chronic Mountain Sickness (CMS).
View Article and Find Full Text PDFInitiation or switch to insulin degludec/insulin aspart in adults with type 2 diabetes in India: Results from a prospective, non-interventional, real-world study.
J Family Med Prim Care
September 2024
Aim: To investigate clinical outcomes in adults with type 2 diabetes (T2D) after insulin degludec/insulin aspart (IDegAsp) treatment in a real-world setting.
Methods: The 26 weeks study involved 1102 adults with T2D who were either initiated with or switched to IDegAsp according to local practice in six countries. It was an open-label, non-interventional study.
Article Synopsis
- - T follicular helper cells (Tfh) play a crucial role in B-cell maturation and antibody production in the immune system but have complex effects on tumor immunity, potentially aiding anti-tumor responses or facilitating tumor growth.
- - Their dual role derives from their ability to manipulate cytokine secretion, which influences other immune cells like cytotoxic T cells and natural killer cells.
- - Understanding Tfh cells is essential for optimizing cancer treatments, as they can serve as biomarkers for immunotherapy response and potential targets for new therapeutic strategies in clinical trials.
Article Synopsis
- The study investigates the relationship between stress and prevalent oral mucosal conditions: leukoplakia, oral lichen planus (OLP), and oral submucous fibrosis (OSMF), highlighting a lack of prior research in this area.
- A total of 280 patients aged 35-60 were analyzed for serum cortisol levels and psychological stress using blood samples and a questionnaire, revealing that OLP patients exhibited the highest cortisol levels, indicating more significant stress, anxiety, and depression.
- The findings suggest that stress is a contributing factor to the development and worsening of OSMF and OLP, with high serum cortisol levels serving as a marker for psychological stress in these conditions.*