Publications by authors named "M Handa"
Genetic Analysis of Vanishing Twin Syndrome Using Next-Generation Sequencing and Short Tandem Repeat Analysis: A Case Report and Literature Review.
J Investig Med High Impact Case Rep
December 2024
Article Synopsis
- Vanishing Twin Syndrome (VTS) is when one fetus in a multiple pregnancy disappears, often discovered through ultrasounds, but its genetic causes are not well understood.
- A case study of a 39-year-old woman who conceived twins via IVF showed that one twin's heartbeat stopped at 11 weeks, confirming VTS while the other developed normally.
- Genetic testing revealed that both fetuses were identical twins with a normal genetic make-up, but the vanished twin exhibited a unique genetic pattern, demonstrating the potential for genetic investigation in cases of VTS.
Research Question: Does tailor-made embryo transfer (TmET), timed with respect to embryonic developmental speed, affect pregnancy outcomes in patients with recurrent implantation failure?
Design: Among 741 patients identified as receptive through endometrial receptivity testing, the clinical pregnancy rates and live birth rates were retrospectively compared between those who underwent standard personalized embryo transfer and those who underwent TmET in hormone replacement therapy cycles. Personalized embryo transfer was performed according to endometrial receptivity test results (standard personalized embryo transfer group) or considering embryonic developmental speed (TmET group). For TmET, the expansion grade of warmed blastocysts was estimated based on each patient's previous embryonic developmental pattern.
The goal of the present work was to formulate zein-decorated rifaximin (RFX) nanosuspension to attain sustained release as well as effectiveness against . The RFX nanosuspension was fabricated by using antisolvent addition method followed by coating using hydroalcoholic zein solution. The optimized RFX-NS and RFX-NS@zein was lyophilized for further spectroscopic evaluations.
View Article and Find Full Text PDFPurpose: Medial meniscus posterior root tears (MMPRT) are a risk factor for knee osteoarthritis. The predominant treatment for MMPRT is transtibial pullout repair, and loop suture remains the gold standard procedure. This study aimed to investigate the structural properties of the meniscus-suture-tibia (MST) complex after loop stitch using ultra-high molecular weight polyethylene (UHMWPE) suture tape of different thicknesses.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the tensile strength of different implants used for pull-out repair of medial meniscus posterior root tears (MMPRT) using porcine knee models.
- It compares three types of fixation implants: double spike plate, metallic interference screw, and resorbable interference screw across various structural properties like maximum load and stiffness.
- Results showed no significant differences in fixation strength among the three implants, suggesting that resorbable screws could be advantageous since they don't require removal.