Publications by authors named "M Hamblin"
Non-coding RNAs (ncRNAs), especially microRNAs (miRNAs) and long ncRNAs (lncRNAs), are essential regulators of processes, such as the cell cycle and apoptosis. In addition to interacting with intracellular complexes and participating in diverse molecular pathways, ncRNAs can be used as clinical diagnostic biomarkers and therapeutic targets for fighting cancer. Studying ncRNA gene clusters is crucial for understanding their role in cancer and developing new treatments.
View Article and Find Full Text PDFMultidrug-resistant tuberculosis (MDR-TB), defined as resistance to the first-line drugs isoniazid and rifampin, is a growing source of global mortality and threatens global control of tuberculosis disease. The diarylquinoline bedaquiline has recently emerged as a highly efficacious drug against MDR-TB and kills Mycobacterium tuberculosis by inhibiting mycobacterial ATP synthase. However, the mechanisms underlying bedaquiline's efficacy against MDR-TB remain unknown.
View Article and Find Full Text PDFViral infections in humans often cause excessive inflammation. In some viral infections, inflammation can be serious and even fatal, while in other infections it can promote viral clearance. Viruses can escape from the host immune system via regulating inflammatory pathways, thus worsening the illness.
View Article and Find Full Text PDFArticle Synopsis
- - Polyamidoamine dendrimers (PAMAM) are synthetic polymers used for targeted drug delivery due to their defined structure and customizable features.
- - The study focused on attaching methotrexate (MTX) to PAMAM loaded with berberine (BER) to target HeLa cancer cells, confirming the preparation through spectroscopy and particle size analysis.
- - Biological tests showed that the MTX-PAMAM-BER combination significantly inhibited tumor cell growth compared to other treatments, highlighting its potential as an effective cancer therapy solution.
Article Synopsis
- The paper originally presented a method for improving the effectiveness of the antibiotic vancomycin by using hybrid magnetic nanoparticles linked to a cell-penetrating peptide.
- The research claimed that this approach enhanced the drug's activity against bacteria, which could lead to better treatment options for infections.
- However, the article was retracted due to concerns over the validity of the results and the methods used in the study, prompting the need for further investigation.