Publications by authors named "M Hallman"
Purpose: Cisplatin-based neoadjuvant chemotherapy (NAC) followed by cystectomy is the standard of care for patients with muscle-invasive bladder cancer (MIBC). Mutations in DNA damage repair genes are associated with pathologic downstaging after NAC. We hypothesized that a combination of biomarker selection and clinical staging would identify patients for cystectomy-sparing active surveillance (AS).
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- Machine learning, particularly deep learning with convolutional neural networks (CNNs), is being used to detect prostate cancer in tissue slides, but sample type differences affect model accuracy.
- Research tested whether CNNs trained on one type of sample (biopsy or radical prostatectomy) could effectively analyze the other type, revealing a significant drop in performance across sample types.
- Results indicated that models performed well on their own sample but poorly on the alternative type, highlighting the need to consider morphological differences in training to improve cancer detection accuracy in clinical settings.*
Article Synopsis
- The study aimed to analyze how paracetamol and its metabolites behave in extremely preterm neonates during treatment for patent ductus arteriosus and to identify factors influencing variability in individual responses.
- Thirty preterm neonates receiving paracetamol were monitored, revealing that the drug was mostly metabolized through the sulfation pathway, which decreased with gestational age, while the glucuronidation pathway increased.
- The results showed no link between the level of drug exposure and clinical outcomes or liver function indicators, suggesting that the dosages used might already achieve optimal effectiveness for ductus closure.
There is a growing interest in the application of stereotactic body radiotherapy (SBRT) for the treatment of oligometastatic cancers. This increasing appeal of SBRT has highlighted the need for more sophisticated radiotherapy techniques that allow high doses of radiation to be delivered to multiple sites while limiting the exposure of neighboring healthy tissue. A major obstacle to achieving this aim has been the occurrence of interfraction target variability: the tendency of both the tumor and the surrounding tissue to undergo day-to-day non-synchronous shifts in position.
View Article and Find Full Text PDFBackground And Objectives: The challenge of identifying preterm infants with bronchopulmonary dysplasia (BPD) that need tracheostomy placement may delay goals of care (GOC) discussions. By identifying infants with a low probability of ventilation liberation, timely GOC discussions may reduce the time to tracheostomy. Our SMART aim was to reduce the postmenstrual age (PMA) of GOC discussions by 20% in infants with BPD and prolonged invasive ventilatory requirement by October 2020.
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