[Patient involvement using the example of the Innovation Fund project "Integrated, cross-sectoral Psychooncology" (isPO)].

Background: In the German health care system, the participation of patients (patient representatives) and the consideration of their perspectives in all phases of research and care are being increasingly demanded. How appropriate patient participation (participation of patient representatives) can be designed is illustrated by the example of the project on the new form of care titled "Integrated, cross-sectoral psychooncology nVF-isPOI" and funded by the Innovation Fund at the Federal Joint Committee.

Method: The realization of patient (representative) participation is presented by the example of the isPO project, taking into account the short form of the Guidance for Reporting Involvement of Patients and the Public (GRIPP2).

Macrophages are activated toward phagocytic lymphoma cell clearance by pentose phosphate pathway inhibition.

Macrophages in the B cell lymphoma microenvironment represent a functional node in progression and therapeutic response. We assessed metabolic regulation of macrophages in the context of therapeutic antibody-mediated phagocytosis. Pentose phosphate pathway (PPP) inhibition induces increased phagocytic lymphoma cell clearance by macrophages in vitro, in primary human chronic lymphocytic leukemia (CLL) patient co-cultures, and in mouse models.