Publications by authors named "M Hague"
Many insects and other animals carry microbial endosymbionts that influence their reproduction and fitness. These relationships only persist if endosymbionts are reliably transmitted from one host generation to the next. Wolbachia are maternally transmitted endosymbionts found in most insect species, but transmission rates can vary across environments.
View Article and Find Full Text PDFMany insects and other animals carry microbial endosymbionts that influence their reproduction and fitness. These relationships only persist if endosymbionts are reliably transmitted from one host generation to the next. are maternally transmitted endosymbionts found in most insect species, but transmission rates can vary across environments.
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- Traits can have molecular mechanisms that link them, leading to trade-offs where improving one trait may hinder another, affecting evolution.
- * In garter snakes, resistance to tetrodotoxin (TTX), a toxin from their newt prey, is achieved through specific mutations in muscle sodium channels, but these mutations also compromise basic sodium functions.
- * These mutations result in reduced muscle performance in the snakes, demonstrating that adaptations for toxin resistance can come with significant costs, impacting their overall effectiveness and evolutionary success in the predator-prey dynamic.
Article Synopsis
- The study aimed to create an animal model that distinguishes between joint instability and inflammation's effects on posttraumatic osteoarthritis (PTOA), proposing that their modified drilling procedure would induce cartilage damage and inflammation without altering gait.
- Twenty-four Yucatan minipigs were divided into two groups, one undergoing the modified intra-articular drilling (mIAD) and the other serving as a sham control, with outcomes assessed through various evaluations 15 weeks post-surgery.
- Results showed that mIAD knees had significantly more cartilage damage and inflammation markers than controls, but no notable changes in gait mechanics, suggesting this model is useful for studying inflammatory roles in PTOA and developing relevant therapies.
Article Synopsis
- - The study investigates how neuromuscular function could influence the risk of posttraumatic osteoarthritis (PTOA) in patients who have undergone anterior cruciate ligament (ACL) reconstruction, highlighting the need for effective analysis tools.
- - Researchers compared the muscle activity patterns of ACL-reconstructed patients to healthy controls using EMG recording during a hop activity, finding that the muscle activation strategies of ACLR patients were globally adapted and symmetrical but differed significantly from those of healthy individuals.
- - The results indicated that smaller thigh muscle girth in the affected leg was the strongest predictor of worse MRI outcomes related to osteoarthritis, suggesting a potential link between muscle activation patterns and PTOA risk that warrants further investigation.