Non-responsive neurons improve population coding of object location.

Understanding how heterogeneous neural populations represent sensory input to give rise to behavior remains a central problem in systems neuroscience. Here we investigated how midbrain neurons within the electrosensory system of code for object location in space. In vivo simultaneous recordings were achieved via Neuropixels probes, high-density electrode arrays, with the stimulus positioned at different locations relative to the animal.

Coding of object location by heterogeneous neural populations with spatially dependent correlations in weakly electric fish.

Understanding how neural populations encode sensory stimuli remains a central problem in neuroscience. Here we performed multi-unit recordings from sensory neural populations in the electrosensory system of the weakly electric fish Apteronotus leptorhynchus in response to stimuli located at different positions along the rostro-caudal axis. Our results reveal that the spatial dependence of correlated activity along receptive fields can help mitigate the deleterious effects that these correlations would otherwise have if they were spatially independent.

Can short PROMs support valid factor-based sub-scores? Example of COMQ-12 in chronic otitis media.

Purpose: Interpretable factor solutions for questionnaire instruments are typically taken as justification for use of factor-based sub-scores. They can indeed articulate content and construct validities of a total and components but do not guarantee criterion validity for clinical application. Our previous documentation of basic psychometric characteristics for a 12-item patient-reported outcome measure in adult chronic otitis media (COMQ-12) justified next appraising criterion validity of sub-scores.

Gains in Quality of Life in Chronic Otitis Media Patients After Surgery, Adjusted for Placebo Bias.

Objective: Using a short-form specific questionnaire, we sought to quantify specific and generic benefits of surgery for chronic otitis media (COM) while adjusting for expectancy (placebo) bias.

Study Design: A prospective observational pretreatment/posttreatment study.

Setting: A national tertiary referral center.

COVCOG 2: Cognitive and Memory Deficits in Long COVID: A Second Publication From the COVID and Cognition Study.

COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been often characterized as a respiratory disease. However, it is increasingly being understood as an infection that impacts multiple systems, and many patients report neurological symptoms. Indeed, there is accumulating evidence for neural damage in some individuals, with recent studies suggesting loss of gray matter in multiple regions, particularly in the left hemisphere.