Publications by authors named "M Haddock"
Objectives: Spatially fractionated radiation therapy (SFRT) intentionally delivers a heterogeneous dose distribution characterized by alternating regions of high and low doses throughout a tumor. This modality may enhance response to subsequent whole tumor radiation in bulky and radioresistant lesions that are historically less responsive to conventional radiation doses alone. The current study presents a single institution experience with modern era SFRT using predominantly a volumetric modulated arc therapy (VMAT) lattice technique.
View Article and Find Full Text PDFBackground: Anal squamous cell carcinoma (ASCC) is a rare cancer with increased occurrence of multiple cancers before and after the ASCC diagnosis. However, there is limited data on this aspect. This multi-institutional analysis aimed to define the occurrence of malignancies before and after ASCC, time trends, impact on survival, and identify prognostic factors.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate the effectiveness and safety of intraoperative radiation therapy (IORT) for treating recurrent cervical and endometrial cancer, along with identifying predictors of postoperative complications and mortality over three years.
- A total of 80 patients were analyzed, revealing a 3-year survival rate of 48.6%, with complications occurring in 20.1% of cases and one patient dying within 30 days post-surgery.
- Key risk factors linked to higher complications and mortality included poor performance status (ECOG PS 2-3), prior chemotherapy/immunotherapy, and the presence of pelvic sidewall involvement.
Article Synopsis
- The study aimed to create and assess EMVision, a system utilizing electromagnetic tracking technology to enhance the placement of brachytherapy applicators, focusing on procedure quality and efficiency.
- EMVision integrates CT imaging and EMT reference frames for precise needle placement, using an automated system that displays real-time 3D visuals and adjusts for anatomy shifts during the procedure.
- Results showed EMVision achieved high accuracy in needle placement, both in phantom tests and human cadaver evaluations, suggesting its potential to streamline brachytherapy procedures and improve training outcomes.
Purpose: To evaluate the safety and efficacy of pencil beam scanning (PBS) proton radiation therapy (RT) in trimodality therapy for esophageal cancer.
Methods And Materials: This prospective pilot study was planned to accrue 30 patients with locally advanced esophageal or gastroesophageal junction carcinoma medically suitable for chemoradiation therapy (CRT) followed by esophagectomy. PBS proton RT consisted of 25 fractions, 50 Gy to tumor + 1 cm and 45 Gy to a 3.