A new biocompatible COF-MCM nanoporous hybrid DDS for pH-controlled delivery of curcumin.

A novel polyimide-bridge covalent organic framework-based (PI-COF) hybrid was synthesized through simple green chemistry between PI-COF and MCM-NH monomers as a pH-sensitive anticancer curcumin (C) delivery system. The synthesized nanohybrid was crystalline in nature with an improved surface area and pore volume compared to the base COF, certified by powder X-ray diffraction spectroscopy and Brunauer-Emmett-Teller technique. Kinetically controlled and sustained curcumin release profiles were investigated using the as-prepared curcumin-loaded drug delivery systems (C@DDSs) in neutral and acidic pH media.

Paternal addiction to cigarettes, alcohol, and opium and the psychological distress of their youths in southeast Iran.

Previous studies have reported inconsistent findings regarding paternal addiction to cigarettes, alcohol, and opium with psychological distress in youths. This study examined the association between paternal addiction to cigarettes, alcohol, and opium and the psychological distress of youths in southeast Iran. This cross-sectional study was conducted on 895 youths (aged 15-35) from the baseline phase of the Rafsanjan Youth Cohort Study (RYCS) whose fathers also participated in the Rafsanjan Cohort Study (RCS).

The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial.

Background: Atherosclerosis is the main process in coronary artery stenosis, which is exacerbated by vitamin D deficiency. This study aims to investigate the relationship between vitamin D deficiency treatment, lipid profile, and C-reactive protein (CRP) in ischemic heart disease (IHD).

Materials And Methods: This is a double-blind, randomized clinical trial involving 44 IHD patients with hypovitaminosis, aged 40-65 years, who were referred to Chamran Specialty Heart Hospital, Isfahan, Iran.

Psychometric Properties of the Cardiac Rehabilitation Self-Efficacy Questionnaire in Heart Failure Patients: A Cross Sectional Study Using Health Action Process Approach Perspective.

Background And Aim: The present study aimed to develop and psychometrically evaluate the exercise self-efficacy tool within the Health Action Process Approach (HAPA) framework among heart failure patients undergoing cardiac rehabilitation.

Methods: This study assessed 205 patients who had suffered heart attacks at the Shahid Chamran Cardiac Rehabilitation Center of Isfahan. Exploratory factor analysis (EFA) was employed to evaluate the construct.

Gender differences in cardiac rehabilitation participation and outcomes: an 18-year retrospective study in Iran.

Background: Cardiac rehabilitation (CR) is crucial for addressing cardiovascular diseases globally, with a specific emphasis on gender differences. Despite its demonstrated benefits for women, there's limited acceptance globally, especially in low- and middle-income countries. The program aims to optimize risk factors and improve overall patient well-being.