Genome Deletions and Rewiring of the Transcriptome Underlying High Antimonite Resistance in sp. SMAs-55.

Microbes have been shown to adapt to stressful or even lethal conditions through displaying genome plasticity. However, how bacteria utilize the ability of genomic plasticity to deal with high antimony (Sb) stress has remained unclear. In this study, the spontaneous mutant strain SMAs-55 of sp.

Prenatal social disadvantage is associated with alterations in functional networks at birth.

Childhood exposure to social disadvantage is a major risk factor for psychiatric disorders and poor developmental, educational, and occupational outcomes, presumably because adverse exposures alter the neurodevelopmental processes that contribute to risk trajectories. Yet, given the limited social mobility in the United States and other countries, childhood social disadvantage is frequently preceded by maternal social disadvantage during pregnancy, potentially altering fetal brain development during a period of high neuroplasticity through hormonal, microbiome, epigenetic, and immune factors that cross the placenta and fetal blood-brain barrier. The current study examines prenatal social disadvantage to determine whether these exposures in utero are associated with alterations in functional brain networks as early as birth.

Linking the transcriptome to physiology: response of the proteome of Cupriavidus metallidurans to changing metal availability.

Cupriavidus metallidurans CH34 is a metal-resistant bacterium. Its metal homeostasis is based on a flow equilibrium of metal ion uptake and efflux reactions, which adapts to changing metal concentrations within an hour. At high metal concentrations, upregulation of the genes for metal efflux systems occurs within minutes.

Antisense transcription is associated with expression of metal resistance determinants in Cupriavidus metallidurans CH34.

Cupriavidus metallidurans is able to thrive in metal-rich environments but also survives metal starvation. Expression of metal resistance determinants in C. metallidurans was investigated on a global scale.

Reliability of sEMG data of back muscles during static submaximal loading situations - Values and pitfalls.

Alterations of trunk muscle activity can be objectified using surface electromyography (sEMG). But for diagnostic purposes reliable reference values are needed. Therefore, the present study evaluated sEMG measurements of representative back muscles concerning their reliability.