Publications by authors named "M H W Starmans"

AI tools in radiology are revolutionising the diagnosis, evaluation, and management of patients. However, there is a major gap between the large number of developed AI tools and those translated into daily clinical practice, which can be primarily attributed to limited usefulness and trust in current AI tools. Instead of technically driven development, little effort has been put into value-based development to ensure AI tools will have a clinically relevant impact on patient care.

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Background: Segmentations are crucial in medical imaging for morphological, volumetric, and radiomics biomarkers. Manual segmentation is accurate but not feasible in clinical workflow, while automatic segmentation generally performs sub-par.

Purpose: To develop a minimally interactive deep learning-based segmentation method for soft-tissue tumors (STTs) on CT and MRI.

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Background: Histopathological growth patterns are one of the strongest prognostic factors in patients with resected colorectal liver metastases. Development of an efficient, objective and ideally automated histopathological growth pattern scoring method can substantially help the implementation of histopathological growth pattern assessment in daily practice and research. This study aimed to develop and validate a deep-learning algorithm, namely neural image compression, to distinguish desmoplastic from non-desmoplastic histopathological growth patterns of colorectal liver metastases based on digital haematoxylin and eosin-stained slides.

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Article Synopsis
  • A study validated a radiomics model that uses MRI imaging to differentiate between lipomas and atypical lipomatous tumors (ALTs), addressing challenges associated with traditional biopsy methods.
  • Three cohorts were analyzed: two for external validation from the US and UK and one for prospective validation from the Netherlands, utilizing automatic and interactive segmentation methods for tumor imaging.
  • The model demonstrated strong performance with area under the curve (AUC) scores ranging from 0.74 to 0.89, matching or exceeding the diagnostic abilities of expert radiologists.
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Article Synopsis
  • The study evaluated the prognostic significance of total tumor volume (TTV) in predicting early recurrence and overall survival in patients with colorectal liver metastases (CRLM) who received systemic therapy followed by local treatment.
  • Results showed that both baseline TTV and changes in TTV after treatment were significantly associated with early recurrence and overall survival, while conventional measures like RECIST1.1 did not show predictive value.
  • Findings were validated in an external patient cohort, confirming that TTV provides important prognostic information beyond traditional clinical factors for patients with initially unresectable CRLM.
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