MuSK-positive myasthenia gravis is rare in the Polish population.

Background And Purpose: MuSK-positive myasthenia gravis (MG) is diagnosed in 0-48% of cases with generalized seronegative MG in different populations. The presence of anti-MuSK antibodies generally relates to a severe course and lack of response to thymectomy. We analyzed for the first time the serology and clinical characteristics of MuSK-positive MG in the Polish population.

[Results of myasthenia treatment with methylprednisolone pulses. Preliminary study].

Eleven patients with generalized myasthenia (type 2b and 3) were studied in whom thymectomy (9 cases) and/or oral steroids did not result in satisfactory improvement. Methylprednisolone was given once a day in an iv slow infusion for five consecutive days (30 mg/kg). In 7 cases this therapy was followed by oral prednisone and/or azathioprine, in 4 cases methylprednisolone infusions were repeated.

[Electrophysiological studies in patients with familial myasthenia and health family members].

Three cases are presented of familial myasthenia gravis: two sisters and their cousin. Healthy members of this family were also examined. Myasthenia gravis was diagnosed on the ground of the clinical and electrophysiological examination (decrement test and SF EMG with jitter evaluation) as well as of the immunological tests (anti AChR antibodies and HLA antigens B8, DR3).