Publications by authors named "M H Sombekke"
Objective: The objective of the study was to determine whether early infratentorial and/or spinal cord lesions are long-term cumulative predictors of disability progression in multiple sclerosis (MS).
Methods: We selected 153 MS patients from the longitudinal Amsterdam MS cohort. Lesion analysis was performed at baseline and year 2.
Background: The presence of asymptomatic spinal cord (SC) lesions in patients with clinically isolated syndrome (CIS) or relapsing-remitting multiple sclerosis (RRMS) predicts conversion to clinically definite multiple sclerosis (CDMS). The relation between asymptomatic SC abnormalities and disability progression warrants further investigation.
Objective: To determine the prognostic value of asymptomatic SC lesions in CIS and early RRMS with respect to the time to disability development.
Background And Objective: We explored which clinical and biochemical variables predict conversion from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (CDMS) in a large international cohort.
Methods: Thirty-three centres provided serum samples from 1047 CIS cases with at least two years' follow-up. Age, sex, clinical presentation, T2-hyperintense lesions, cerebrospinal fluid (CSF) oligoclonal bands (OCBs), CSF IgG index, CSF cell count, serum 25-hydroxyvitamin D3 (25-OH-D), cotinine and IgG titres against Epstein-Barr nuclear antigen 1 (EBNA-1) and cytomegalovirus were tested for association with risk of CDMS.
Cervical spinal cord volume loss is related to clinical disability progression in multiple sclerosis.
J Neurol Neurosurg Psychiatry
April 2015
Objective: To examine the temporal evolution of spinal cord (SC) atrophy in multiple sclerosis (MS), and its association with clinical progression in a large MS cohort.
Methods: A total of 352 patients from two centres with MS (relapsing remitting MS (RRMS): 256, secondary progressive MS (SPMS): 73, primary progressive MS (PPMS): 23) were included. Clinical and MRI parameters were obtained at baseline, after 12 months and 24 months of follow-up.
Article Synopsis
- The study aimed to investigate differences in spinal cord atrophy among multiple sclerosis (MS) subtypes and its potential as a diagnostic tool alongside other MRI markers.
- The study involved analyzing the upper cervical cord cross-sectional area (UCCA) and correlating it with clinical disability in 440 MS patients from two centers, categorized into relapsing-remitting (RR), secondary-progressive (SP), and primary-progressive (PP) MS.
- Results showed that patients with SP and PP MS had significantly smaller UCCA compared to RR MS, and UCCA correlated inversely with disability scores, suggesting its importance in assessing clinical status in MS.