Using Mixed Methods to Evaluate Risk Minimisation Programs in Europe and the USA: An Innovative Blueprint.

Background: Significant methodological shortcomings have been documented to date in risk minimisation program evaluations for medicinal products, including overreliance on survey methods alone. Recently updated guidances from the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) recommend the use of frameworks and mixed methods designs to improve the rigor of these assessments.

Objective: The purpose of this paper was to exemplify how a mixed methods approach, guided by an implementation science framework, can be used to design the evaluation of a risk minimisation program.

Exploring registered dietitians' contributions and educational needs in primary care: Insights for health leaders.

Registered Dietitians (RDs) are essential professionals within Canadian Team-Based Primary Care (TBPC). RDs utilize practice competencies to ensure provision of high-quality care while working closely with other TBPC members. To fill in the gaps in the literature, the study's objective was to explore RDs' perception of their contributions to TBPC settings and their educational needs.

Estimated Cancer Risk in Females Who Meet the Criteria to Exit Cervical Cancer Screening.

Importance: Cervical screening guidelines in the US recommend that most females can exit routine screening at age 65 years following 2 recent consecutive negative cotest results (concurrent human papillomavirus and cytology tests). However, empirical data on the subsequent risks of cancer and cancer death in this subgroup of females are limited.

Objective: To estimate the risks of cervical cancer and cervical cancer death among females who meet the cotesting criteria to exit screening.

Epigenetic enhancement of adoptive T cell immunotherapy.

Isshiki et al. and Porazzi et al. report that inhibiting enhancer of zeste homolog 1 (EZH1) and EZH2 enhances chimeric antigen receptor (CAR)/T cell receptor (TCR)-based therapies by reprogramming tumors to be more immunogenic and improving T cell phenotype and demonstrate the efficacy of this combination in preclinical models across hematologic and solid cancers.

From Polymers to Rings and Back Again: Chemical Recycling of Polyesters to Macrolactones.

Cyclic anhydride and epoxide ring-opening copolymerization is a versatile and controlled route to make polyesters, gaining attention in different application sectors but so far the chemical recycling of these polyesters to cyclic monomers is under-explored. Here, the catalytic chemical recycling of aliphatic polyesters to selectively form 16- and 18-membered lactones is presented. The recycling reactions are catalysed using commercial tin octoate and conducted in the polymer melt (230 °C) resulting in high conversions to the macro-lactones (>90%).