Publications by authors named "M H Silber"
Proliferating tumor cells take up glutamine for anabolic processes, engendering glutamine deficiency in the tumor microenvironment. How this might impact immune cells is not well understood. Using multiple mouse models of soft tissue sarcomas, glutamine antagonists, as well as genetic and pharmacological inhibition of glutamine utilization, we found that the number and frequency of conventional dendritic cells (cDCs) is dependent on microenvironmental glutamine levels.
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- - The study investigates isolated REM sleep behavior disorder (iRBD) and its links to neurodegenerative diseases, focusing on gender differences and younger adults, which are less explored compared to older males.
- - Researchers followed 372 participants (186 women and 186 men with iRBD), finding that women were diagnosed at a younger age than men and that over 12% converted to a neurodegenerative disorder within roughly 6 years.
- - Key findings indicate that older age at diagnosis is a significant factor for phenoconversion risk, with lower risk observed in those using antidepressants or having chronic pain, while higher risk was noted in individuals with vascular issues.
Unlabelled: Proliferating tumor cells take up glutamine for anabolic processes engendering glutamine deficiency in the tumor microenvironment. How this might impact immune cells is not well understood. Using multiple mouse models of soft tissue sarcomas, glutamine antagonists, as well as genetic and pharmacological inhibition of glutamine utilization, we found that the number and frequency of conventional dendritic cells (cDC) is dependent on microenvironmental glutamine levels.
View Article and Find Full Text PDFProblem: Accelerated placental aging is linked to abnormal fetal growth, preeclampsia (PE), and preterm birth (PTB). NANOG, a transcription factor, is known for its role in cellular reprogramming, self-renewal, and clonogenic growth. Its expression is regulated by Kruppel-like factor 4 (KLF4), which functions as both a transcriptional activator and repressor.
View Article and Find Full Text PDFStudy Objectives: Serum ferritin levels are used to determine the need for iron supplementation in patients with restless legs syndrome. The purpose of this study was to determine whether immunoassay measurement of serum ferritin yields varying levels according to different manufacturers' assays, with resultant variation in cutoff values.
Methods: We compared serum ferritin levels using 116 clinical samples assessed by the Beckman and Roche methods.