Publications by authors named "M H Shamir"
Background: Epilepsy in dogs and humans is associated with blood-brain barrier (BBB) dysfunction (BBBD), which may involve dysfunction of tight junction (TJ) proteins, matrix metalloproteases, and astrocytes. Imaging techniques to assess BBB integrity, to identify potential treatment strategies, have not yet been evaluated in veterinary medicine.
Hypothesis: Some dogs with idiopathic epilepsy (IE) will exhibit BBBD.
Two female (FL 1, FL 2) and one male (ML) 11-wk-old, intact, captive African lion cubs () were presented with a history of mild vestibular signs. Initial serum vitamin A concentrations were low (140 nmol/L) for ML. Calvarial hyperostosis was confirmed using computed tomography (CT) of the head and cervical vertebrae in each cub.
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- Coiled-coil domains (CCDs) are crucial for regulating cellular functions and diseases by influencing protein interactions, particularly in the STIL protein, which is linked to cancer and metastasis.
- The oligomerization of the STIL CCD peptide, involving disordered and structured regions, was characterized using advanced techniques like ultracentrifugation and spectroscopy to determine how STIL assembles into dimers and tetramers at different concentrations.
- The study provides insights into the structural biology of STIL, revealing how its oligomerization may be targeted for potential anti-cancer therapies.
This paper reports the effect of as-deposited surface conditions on the fatigue strength of an additively manufactured titanium alloy, Ti-6Al-4V (WAAM Ti64). First, the local stress concentration caused by the surface waviness was quantified using a metrology technique and computer modelling. Fatigue tests were conducted under bending loads at a cyclic load ratio of 0.
View Article and Find Full Text PDFBackground: Blood-brain barrier (BBB) permeability can be assessed quantitatively using advanced imaging analysis.
Hypothesis/objectives: Quantification and characterization of blood-brain barrier dysfunction (BBBD) patterns in dogs with brain tumors can provide useful information about tumor biology and assist in distinguishing between gliomas and meningiomas.
Animals: Seventy-eight hospitalized dogs with brain tumors and 12 control dogs without brain tumors.