Tongue and teeth hyperpigmentation in etoposide, prednisolone, vincristine, and cyclophosphamide regimen in the treatment of cutaneous lymphoma.

Cutaneous extranodal non-Hodgkin lymphoma is a rare cancer and chemotherapeutic agents like etoposide, vincristine and cyclophosphamide are the drug of choice, which rarely cause hyperpigmentation in skin and nails. However, herein we present a case of hyperpigmentation that was seen in tongue and even in teeth. The hyperpigmentation of the tongue and teeth occurred shortly after the initiation of chemotherapy.

Leptomeningeal Carcinomatosis of Metastatic Primary Prostate Cancer.

Leptomeningeal carcinomatosis (LC) is an uncommon complication of cancer in which the disease metastasizes to the meninges; it is estimated that this occurs in 5% of cancer patients and is most often terminal. LC has a median survival time of approximately 15.7 weeks [Leal et al.

Synthesis, Molecular Docking and Biological Evaluation of Iminostilbene Linked 1,2,3-Triazole Pharmacophores as Promising Anti- Anxiety and Anti-Inflammatory Agents.

Background: Iminostilbene and 1,2,3-triazole ring containing compounds are considered as beneficial substrates in drug design.

Objectives: This study was aimed at the synthesis of novel series of iminostilbene linked 1,2,3- triazole pharmacophores (7c-n) by Cu(I) catalyzed 1,3 dipolar cycloaddition reaction between 5- (Prop-2-yn-1-yl)-5H-dibenzo[b,f]azepine (7b) and various substituted azidobenzene derivatives (3cn).

Methods: The chemical structures of compounds were confirmed by H NMR, C NMR, LC-MS and molecular docking studies were carried out through HEX docking software.