Publications by authors named "M H Rosenbloom"
Background: Alzheimer's disease (AD) is characterized by cerebral amyloid plaques and neurofibrillary tangles and disruption of large-scale brain networks (LSBNs). Transcranial magnetic stimulation (TMS) has emerged as a potential non-invasive AD treatment that may serve as an adjunct therapy with FDA approved medications.
Methods: We conducted a 10-subject open label, single site study evaluating the effect of functional connectivity-resting state functional MRI guided-approach to TMS targeting with dysfunctional LSBNs in subjects with biomarker-confirmed early-stage AD (https://clinicaltrials.
Intracerebral hemorrhage following mild ARIA-H in an APOE ε2 carrier receiving lecanemab.
Alzheimers Res Ther
December 2024
Objective: Report a case of an apolipoprotein E (APOE)ε2 carrier receiving lecanemab who developed late onset intracerebral hemorrhage (ICH) following amyloid-related imaging abnormalities-hemorrhage (ARIA-H).
Method: We detail the history and neuroimaging findings of a 73-year-old male with Alzheimer's disease (APOEε2/ε3 status) who developed ICH after mild ARIA-H and suffering a fall.
Results: The patient developed mild ARIA-H after his 13th infusion that was proceeded by left temporo-occipital hemorrhage following his 14th infusion.
Article Synopsis
- The FDA has approved lecanemab for early-stage Alzheimer's disease, marking a significant advancement in treating neurodegenerative conditions but also presenting various challenges for healthcare institutions.
- There is a lack of resources for institutions to effectively establish and manage a lecanemab treatment program, prompting the need for a structured framework.
- The report outlines a three-stage implementation study (feasibility assessment, operations, and monitoring), concluding that lecanemab's clinical integration is feasible with proper project management, financial sustainability analysis, and efficient electronic record tools.
A 53-year-old male presented following cardiac arrest, followed by cardiopulmonary resuscitation. He was found to have myocardial infarction, bihemispheric cerebral embolization and mitral valve endocarditis. Mitral valve replacement was performed and was detected on PCR.
View Article and Find Full Text PDFA female in her 70s presented with altered mental status, left eye pain, ophthalmalgia, and diplopia following a fall. Brain MRI demonstrated contrast-enhancing left peri-insular T2 hyperintense changes that was read as possible herpes simplex encephalitis by neuroradiology. Cerebral angiogram revealed a Barrow Type D left sided carotid cavernous fistula.
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