Publications by authors named "M H Rasch"

Article Synopsis
  • Gremlin-1 has been linked to liver fibrosis in metabolic dysfunction-associated steatohepatitis (MASH) by inhibiting BMP signaling, making it a potential focus for therapy.* -
  • In studies using rat and human models, blocking Gremlin-1 with antibodies did not reduce liver inflammation or fibrosis, despite its increased presence in specific myofibroblast cells.* -
  • Findings indicate that Gremlin-1 does not significantly contribute to liver fibrosis development and is not a viable target for treatment due to its limited role in the disease process.*
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Article Synopsis
  • Anifrolumab is a monoclonal antibody used to treat systemic lupus erythematosus (SLE) but comes with a heightened risk of viral infections, notably herpes zoster (HZ), with reported rates of 6.1% in clinical trials.
  • In two unique cases, SLE patients on anifrolumab experienced severe herpesvirus infections—disseminated HSV-2 and HZ encephalitis—marking a concerning new trend not previously documented.
  • The findings underline the importance of assessing patients' viral infection history and recommending vaccinations, like the recombinant zoster vaccine, before starting anifrolumab therapy to mitigate infection risks.
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Analog in-memory computing is a promising future technology for efficiently accelerating deep learning networks. While using in-memory computing to accelerate the inference phase has been studied extensively, accelerating the training phase has received less attention, despite its arguably much larger compute demand to accelerate. While some analog in-memory training algorithms have been suggested, they either invoke significant amount of auxiliary digital compute-accumulating the gradient in digital floating point precision, limiting the potential speed-up-or suffer from the need for near perfectly programming reference conductance values to establish an algorithmic zero point.

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To evaluate tumour necrosis factor inhibitor (TNFi) drug-levels and presence of anti-drug antibodies (ADAb) in patients with inflammatory arthritis who taper TNFi compared to TNFi continuation. Patients with rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis on stable TNFi dose and in low disease activity ≥ 12 months were randomised (2:1) to disease activity-guided tapering or control. Blood samples at baseline, 12- and 18-months were evaluated for TNFi drug-levels and ADAb.

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A critical bottleneck for the training of large neural networks (NNs) is communication with off-chip memory. A promising mitigation effort consists of integrating crossbar arrays of analogue memories in the Back-End-Of-Line, to store the NN parameters and efficiently perform the required synaptic operations. The "" algorithm was developed to facilitate NN training in the presence of device nonidealities.

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