Publications by authors named "M H Pool"
Article Synopsis
- * A new imaging agent, AKRO-6qcICG, can be applied to the surface of these tumors and helps surgeons see where cancer cells remain during surgery using near-infrared fluorescence.
- * In studies with patients, AKRO-6qcICG showed excellent sensitivity (100%) in detecting remaining cancer cells, indicating it could be a valuable tool to improve surgical outcomes and minimize additional treatments.
Purpose: Cysteine cathepsins are proteases that play a role in normal cellular physiology and neoplastic transformation. Elevated expression and enzymatic activity of cathepsins in breast cancer (BCa) indicates their potential as a target for tumor imaging. In particular cathepsin B (CTSB), L (CTSL), and S (CTSS) are used as targets for near-infrared (NIR) fluorescence imaging (FI), a technique that allows real-time intraoperative tumor visualization and resection margin assessment.
View Article and Find Full Text PDFOrchestrated centers for the production of proteins or "translation factories".
Wiley Interdiscip Rev RNA
July 2024
The mechanics of how proteins are generated from mRNA is increasingly well understood. However, much less is known about how protein production is coordinated and orchestrated within the crowded intracellular environment, especially in eukaryotic cells. Recent studies suggest that localized sites exist for the coordinated production of specific proteins.
View Article and Find Full Text PDFArticle Synopsis
- Integrating genetic data into conservation management in Latin America requires collaboration between researchers and managers to address biodiversity challenges.
- A survey of 468 conservation managers across 21 Latin American countries showed that 65% had engaged in genetic assessments, finding them valuable for management decisions.
- The study identified barriers for the 35% of respondents who hadn't used genetic assessments, including limited funding, lack of lab facilities, and insufficient trained personnel.
Article Synopsis
- The text highlights the complexity of the tissue microenvironment (TiME) and the challenges in understanding its organization over time and space.
- It discusses recent advancements in engineering and data science that enable detailed study of TiME, although many innovations remain isolated without integration.
- The review offers a comprehensive overview of various technologies and their applications, aiming to enhance understanding of TiME's role in diseases and development, while also emphasizing the importance of collaboration in research efforts.