Publications by authors named "M H Panning"
Article Synopsis
- The executive summary outlines evidence-based recommendations for diagnosing and treating nosocomial pneumonia, focusing on practical guidelines for healthcare providers in Germany.
- It was developed through a systematic review process by an interdisciplinary panel, with the help of an independent methodologist, and presents 26 total recommendations, including ones based on strong evidence and expert consensus.
- Key recommendations include distinguishing patients at risk for multidrug-resistant pathogens, limitations of routine bacterial PCR testing, and guidelines for antibiotic therapy, emphasizing focused treatments and the importance of rapidly de-escalating unnecessary antibiotics when patients stabilize.
Article Synopsis
- The study examined how often and significantly Herpes simplex virus (HSV) reactivates in patients with community-acquired pneumonia (CAP) and identified potential risk factors.
- It analyzed data from adult CAP patients in the CAPNETZ study (2007-2017), where both sputum and blood samples were tested for HSV, focusing on demographics and clinical outcomes.
- Results showed that HSV-1 was present in 12.2% of patients, but its presence didn’t correlate with worse outcomes, suggesting that while HSV reactivation is common, it may not complicate the disease significantly.
Article Synopsis
- - The study evaluated the effectiveness of antigen rapid diagnostic tests (Ag-RDT) and RT-qPCR in detecting infectious SARS-CoV-2 by comparing them with virus isolation as a reference.
- - Out of 20 studies reviewed, both tests showed varying levels of sensitivity and specificity, with Ag-RDT showing 93% sensitivity and 87% specificity, while RT-qPCR had 98% sensitivity but only 45% specificity.
- - The findings highlight that while Ag-RDT can identify most infectious samples, RT-qPCR's high sensitivity doesn't necessarily indicate true infectivity due to its low specificity, and both tests have limitations that should be considered when interpreting results.
Background: Community-acquired pneumonia (CAP) is a major global cause of death and hospitalization. Bacteria or community-acquired viruses (CARVs) cause CAP. COVID-19 associated restrictions effectively reduced the circulation of CARVs.
View Article and Find Full Text PDFCOVID-19 vaccination has been shown to prevent and reduce the severity of COVID-19 disease. The aim of this study was to explore the cardioprotective effect of COVID-19 vaccination in hospitalized COVID-19 patients. In this retrospective, single-center cohort study, we included hospitalized COVID-19 patients with confirmed vaccination status from July 2021 to February 2022.
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