Systolic blood pressure ≤110 mm Hg is associated with severe coronary microvascular ischemia and higher risk for ventricular arrhythmias in hypertrophic cardiomyopathy.

Background: Coronary microvascular dysfunction (CMD) and hypertension (HTN) occur frequently in hypertrophic cardiomyopathy (HCM), but whether blood pressure (BP) influences CMD and outcomes is unknown.

Objective: The purpose of this study was to test the hypothesis that HTN is associated with worse CMD and outcomes.

Methods: This retrospective study included 690 HCM patients.

Hypoxia-specific imaging in patients with lymphoma undergoing CAR-T therapy.

Purpose: Intratumoral hypoxia in non-Hodgkin's Lymphoma (NHL) may interfere with chimeric antigen receptor T-cell (CAR-T) function. We conducted a single-center pilot study (clinicaltrials.gov ID NCT04409314) of [F]fluoroazomycin arabinoside, a hypoxia-specific radiotracer abbreviated as [F]FAZA, to assess the feasibility of this positron emission tomography (PET) imaging modality in this population.

A feasibility study for quantitative assessment of cerebrovascular malformations using flutriciclamide ([F]GE-180) PET/MRI.

Aim: Neuroinflammation plays a key role in both the pathogenesis and the progression of cerebral cavernous malformations (CCM). Flutriciclamide ([F]GE-180) is a translocator protein (TSPO) targeting positron emission tomography (PET) tracer, developed for imaging neuroinflammation. The objectives of this study were to describe characteristics of flutriciclamide uptake in different brain tissue regions in CCM patients compared to controls, and to evaluate flutriciclamide uptake and iron deposition within CCM lesions.

PSMA PET Validates Higher Rates of Metastatic Disease for European Association of Urology Biochemical Recurrence Risk Groups: An International Multicenter Study.

The European Association of Urology (EAU) prostate cancer guidelines panel recommends risk groups for biochemical recurrence (BCR) of prostate cancer to identify men at high risk of progression or metastatic disease. The rapidly growing availability of PSMA-directed PET imaging will impact prostate cancer staging. We determined the rates of local and metastatic disease in BCR and biochemical persistence (BCP) of prostate cancer stratified by EAU BCR risk groups and BCP.

Superior sensitivity of F-fluorocholine: PET localization in primary hyperparathyroidism.

Background: Preoperative parathyroid imaging guides surgeons during parathyroidectomy. This study evaluates the clinical impact of F-fluorocholine positron emission tomography for preoperative parathyroid localization on patients with primary hyperparathyroidism.

Methods: Patients with primary hyperparathyroidism and indications for parathyroidectomy had simultaneous F-fluorocholine positron emission tomography imaging/magnetic resonance imaging.