Publications by authors named "M H Paclet"
Article Synopsis
- The study aimed to determine if serum calprotectin levels could predict declines in kidney function among patients with ANCA-associated vasculitis (AAV) undergoing maintenance therapy.
- Serum calprotectin levels were measured at the start and after 6 months in patients in remission, and an increase was linked to a higher risk of significant renal function decline and relapse of the disease.
- The findings suggest that monitoring calprotectin levels could be important for identifying patients at risk of worsening kidney function in the following year.
Human kallikrein-kinin system (KKS) is a proteolytic cascade with two serine-protease zymogen couples (Factor XII and prekallikrein (PK) and their activated forms, FXIIa, PKa, respectively), releasing bradykinin by cleavage of native high-molecular-weight kininogen (nHK) into cleaved HK. For KKS investigation in human plasma, this cascade is usually triggered on ice eventually by mixing with purified proteins. It has been established that purified FXIIa, PK, and nHK required a fixed order and timing for mixing protein on ice to ensure reproducibility of testing, we investigated the activation kinetics of both enzymes.
View Article and Find Full Text PDFReactive oxygen species (ROS), produced by the phagocyte NADPH oxidase, NOX2, are involved in many leukocyte functions. An excessive or inappropriate ROS production can lead to oxidative stress and tissue damage. On the other hand, an absence of ROS production due to a lack of a functional NADPH oxidase is associated with recurrent infections as well as inflammation disorders.
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