Publications by authors named "M H Nam"
Article Synopsis
- Alzheimer's disease (AD) is characterized by cognitive decline and specific brain changes, necessitating the development of effective animal models to study it.
- Current transgenic mouse models have limitations in capturing the full complexity of human AD pathology and their interactions.
- The novel APP/PS1-TauP301L-Adeno mouse model enhances understanding of AD mechanisms by inducing significant pathological symptoms, revealing the exacerbating effect of severe reactive astrogliosis on amyloid-β plaques and neurofibrillary tangles.
Article Synopsis
- Young infants initially can differentiate sounds from various languages, supporting the perceptual narrowing hypothesis, which suggests they become less sensitive to non-native phonemes as they grow.
- This study investigated how 4-6 month-old Korean and Japanese infants respond to specific Thai phoneme contrasts, specifically looking at their ability to discriminate between different stop sounds based on voice onset time (VOT).
- Findings revealed that Korean infants were sensitive to the pre-voiced vs. voiceless contrast, while Japanese infants were better at distinguishing the voiceless vs. voiceless aspirated sounds, highlighting significant differences in language input's impact on infants' phoneme discrimination abilities.
Transcranial brain stimulation is a promising technology for safe modulation of brain function without invasive procedures. Recent advances in transcranial optogenetic techniques with external light sources, using upconversion particles and highly sensitive opsins, have shown promise for precise neuromodulation with improved spatial resolution in deeper brain regions. However, these methods have not yet been used to selectively excite or inhibit specific neural populations in multiple brain regions.
View Article and Find Full Text PDFTraumatic optic neuropathies cause the death of retinal ganglion cells (RGCs) and axon degeneration. This is a result of the blockage of neurotrophic factor (NTF) supply from the brain and a vicious cycle of neurotoxicity, possibly mediated by increased levels of retinal Zn . Ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) are two NTFs that are known to support RGC survival and promote axon regeneration.
View Article and Find Full Text PDFUntil now, many researchers have conducted evaluations on hippocampi for analyses of cognitive dysfunction models using scopolamine. However, depending on the purposes of these analyses, there are differences in the experimental results for the hippocampi and cortexes. Therefore, this study intends to compare various analyses of cognitive dysfunction after scopolamine administration with each other in hippocampi and cortexes.
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