Attributable mortality of vancomycin resistance in ampicillin-resistant bacteremia in Denmark and the Netherlands: A matched cohort study.

Objective: To study whether replacement of nosocomial ampicillin-resistant (ARE) clones by vancomycin-resistant (VRE), belonging to the same genetic lineages, increases mortality in patients with bacteremia, and to evaluate whether any such increase is mediated by a delay in appropriate antibiotic therapy.

Design: Retrospective, matched-cohort study.

Setting: The study included 20 Dutch and Danish hospitals from 2009 to 2014.

SARS-CoV-2 mucosal antibody development and persistence and their relation to viral load and COVID-19 symptoms.

Although serological studies have shown that antibodies against SARS-CoV-2 play an important role in protection against (re)infection, the dynamics of mucosal antibodies during primary infection and their potential impact on viral load and the resolution of disease symptoms remain unclear. During the first pandemic wave, we assessed the longitudinal nasal antibody response in index cases with mild COVID-19 and their household contacts. Nasal and serum antibody responses were analysed for up to nine months.

Why psychiatry is different - challenges and difficulties in managing a nosocomial outbreak of coronavirus disease (COVID-19) in hospital care.

Objective: Coronavirus disease (COVID-19) was officially declared a pandemic in March 2020. Many cases of COVID-19 are nosocomial, but to the best of our knowledge, no nosocomial outbreaks on psychiatric departments of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported in Europe. The different nature of psychiatry makes outbreak management more difficult.

[Diagnostic algorithm for COVID-19 at the ER].

Objective: Evaluation of a diagnostic algorithm for estimating the risk of COVID-19 in patients who are referred to an emergency department for being suspected of having the disease.

Design: Retrospective study.

Method: Patients with fever with no apparent cause and patients with recently developed respiratory symptoms, whether or not in combination with fever, were routinely given a PCR test, blood tests (lymphocyte count and LDH levels) and a chest CT scan.

An electronic trigger tool to optimise intravenous to oral antibiotic switch: a controlled, interrupted time series study.

Background: Timely switch from intravenous (iv) antibiotics to oral therapy is a key component of antimicrobial stewardship programs in order to improve patient safety, promote early discharge and reduce costs. We have introduced a time-efficient and easily implementable intervention that relies on a computerized trigger tool, which identifies patients who are candidates for an iv to oral antibiotic switch.

Methods: The intervention was introduced on all internal medicine wards in a teaching hospital.