Long-Term Predictive Modelling of the Craniofacial Complex Using Machine Learning on 2D Cephalometric Radiographs.

Objective: This study aimed to predict long-term growth-related changes in skeletal and dental relationships within the craniofacial complex using machine learning (ML) models.

Materials And Methods: Cephalometric radiographs from 301 subjects, taken at pre-pubertal (T1, age 11) and post-pubertal stages (T2, age 18), were analysed. Three ML models-Lasso regression, Random Forest, and Support Vector Regression (SVR)-were trained on a subset of 240 subjects, while 61 subjects were used for testing.

Roles for Prlhr/GPR10 and Npffr2/GPR74 in Feeding Responses to PrRP.

Several groups of neurons in the NTS suppress food intake, including Prlh-expressing neurons (NTS cells). Not only does the artificial activation of NTS cells decrease feeding, but also the expression of Prlh (which encodes the neuropeptide PrRP) and neurotransmission by NTS neurons contributes to the restraint of food intake and body weight, especially in animals fed a high fat diet (HFD). We used animals lacking PrRP receptors GPR10 and/or GRP74 (encoded by Prlhr and Npffr2, respectively) to determine roles for each in the restraint of food intake and body weight by the increased expression of Prlh in NTS neurons (NTS mice) and in response to the anorectic PrRP analog, p52.

Middle school teachers' implementation and perceptions of automated writing evaluation.

Despite research supporting the efficacy of Automated Writing Evaluation (AWE) in improving writing outcomes, inconsistent implementation by teachers raises concerns about the efficacy of these systems in practice. However, little is known about what factors influence teachers' implementation and perceptions of AWE. This study examined the relationship between teachers' implementation and perceptions of the MI Write AWE system, seeking to identify actionable factors that could enhance AWE implementation and acceptance in the future.

Engaging adolescents and young adults in decisions about return of genomic research results: study protocol for a mixed-methods longitudinal clinical trial protocol.

Background: To protect minors' future autonomy, professional organizations have historically discouraged returning predictive adult-onset genetic test results and carrier status to children. Recent clinical guidance diverges from this norm, suggesting that when minors have genomic sequencing performed for clinical purposes, parents and children should have the opportunity to learn secondary findings, including for some adult-onset conditions. While parents can currently opt in or out of receiving their child's secondary findings, the American Society of Human Genetics Workgroup on Pediatric Genetic and Genomic Testing suggests including adolescents in the decision-making process.