Publications by authors named "M H Molijn"

Background: Routine HCV NAT minipool screening (48 donations) of all blood donations was implemented in July 1999 and was combined with HIV NAT in November 2000. This report describes the validation of the NAT methods and the results of quality control testing.

Study Design And Methods: Nucleic acid was extracted from 2-mL plasma samples by using an automated silica-based extraction method (NucliSens Extractor, Organon Teknika).

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Background And Objectives: Since July 1 1999, four laboratories in the Netherlands have been routinely screening plasma minipools for the release of labile blood components utilizing hepatitis C virus nucleic acid amplification technology (HCV NAT). This report describes the performance evaluation of the HCV NAT method and the quality control results obtained during 6 months of routine screening.

Materials And Methods: Plasma minipools of 48 donations were prepared on a Tecan Genesis robot.

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Background And Objectives: The usefulness of testing for antibody to hepatitis B core antigen (anti-HBc) as a surrogate marker for non-A, non-B hepatitis can no longer be clearly established in the face of anti-hepatitis C virus testing. Application of anti-HBc testing in blood donors for detection of hepatitis B in addition to hepatitis B surface antigen testing (HbsAg) is a matter of debate.

Materials And Methods: We examined the serology and risk analysis data in a group of first-time blood donors.

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Objective: To determine the feasibility and acceptability for the blood donor of an intensified blood donor interviewing procedure on high-risk factors for infectious diseases. To answer the question whether an intensified blood donor interviewing procedure would lead to an unacceptable loss of blood donors.

Design: Feasibility study.

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