Publications by authors named "M H Mileva"

The highly valued oil of Mill. (Rosaceae), widely used in high perfumery, cosmetics, and other spheres of human life, obliges us to know and study the safety profile of the product obtained from the water-steam distillation of fresh rose petals. The genotoxicity of the essential oil (EsO) has not been thoroughly studied despite its wide range of applications.

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In this study, we aimed to assess the activity of the essential oils from four Bulgarian oil-bearing roses Mill., L., L.

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Background: Peptide receptor radionuclide therapy (PRRT) with [Lu]Lu-DOTA-TATE has emerged as a promising treatment for gastroenteropancreatic neuroendocrine tumours (GEP-NETs). Its treatment protocol is currently standardised for all patients, resulting in different patient outcomes. This study investigates the variability of tumours and organs-at-risk (kidneys and red marrow) dosimetric parameters across treatment cycles in patients with pancreatic and intestinal NETs.

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Article Synopsis
  • The ZEPHIR clinical trial aimed to assess how [89Zr]trastuzumab-PET/CT and [18F]FDG-PET/CT can predict outcomes in patients with advanced HER2-positive breast cancer receiving trastuzumab emtansine (T-DM1).
  • Researchers integrated imaging data from PET/CT scans and gene expression data from biopsy samples to understand the relationship between drug uptake and biological processes in the tumors.
  • The study revealed that low uptake of [89Zr]trastuzumab was linked to ECM-related gene pathways, while high uptake correlated with immune responses, highlighting the importance of ECM in affecting drug uptake and treatment response in these patients.
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Tumor-induced osteomalacia (TIO) is a paraneoplastic syndrome caused by abnormally high levels of fibroblast growth factor 23 (FGF-23), most commonly produced and secreted by small phosphaturic mesenchymal tumors (PMT). These tumors can show various anatomic locations throughout soft tissue and bone. The presence of the tumor itself rarely causes symptoms.

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