Publications by authors named "M H Kjeldsen"

Article Synopsis
  • The management of advanced ovarian cancer (AOC) has improved due to molecular diagnostics that help predict how patients will respond to PARP inhibitors, particularly based on homologous recombination deficiency (HRD) status.
  • This study analyzed tumor samples from a clinical trial to investigate why HRD status isn't always a reliable indicator of sensitivity to PARP inhibitors.
  • Key findings included that some HRD-negative samples showed responses to treatment despite their status, while some HRD-positive samples did not, emphasizing the need to consider other genetic factors beyond HRD status.
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Introduction: A significant proportion of patients do not achieve seizure freedom despite treatment attempts with two different anti-seizure medications (ASMs). A subset may not truly have drug-resistant epilepsy ("pseudoresistant"), while rapid referral of patients with genuine drug-resistant epilepsy to surgery is mandated. This study was designed to evaluate a structured and intensive treatment course with the objective of promptly identifying cases of pseudoresistance and accelerating the time to referral to epilepsy surgery.

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Objective: This national study aimed to estimate the prevalence of the transgender and gender-diverse identity and to assess the level of gender congruence, body dissatisfaction and quality of life among patients with eating disorders in Denmark.

Method: Patients with eating disorders were compared to a matched non-clinical comparison group. The survey included the Eating Disorder Examination Questionnaire and assessment of body dissatisfaction, gender congruence and quality of life.

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Limited literature is available identifying phenotypical traits related to enteric methane (CH) production from dairy cows, despite its relevance in relation to breeding for animals with a low CH yield (g/kg DMI) and the derived consequences hereof. This study aimed to investigate the relationships between CH yield and different animal phenotypes when 16 second-parity dairy cows, fitted with a ruminal cannula, were fed 2 diets differing in forage/concentrate ratio in a crossover design. The diets had either a low forage proportion (35% on DM basis; F35) or a high forage proportion (63% on DM basis; F63).

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Automated measurements of the ratio of concentrations of methane and carbon dioxide, [CH]:[CO], in breath from individual animals (the so-called "sniffer technique") and estimated CO production can be used to estimate CH production, provided that CO production can be reliably calculated. This would allow CH production from individual cows to be estimated in large cohorts of cows, whereby ranking of cows according to their CH production might become possible and their values could be used for breeding of low CH-emitting animals. Estimates of CO production are typically based on predictions of heat production, which can be calculated from body weight (BW), energy-corrected milk yield, and days of pregnancy.

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