Publications by authors named "M H K Marklund"

Background: Intake of trans-fatty acids (TFAs) is an established risk factor for cardiovascular disease. In April 2023, Nigeria passed regulations limiting TFA content in foods, fats, and oils, but the current level of TFA exposure in the Nigerian population is unknown.

Objectives: To quantify trans-fatty acid (TFA) biomarkers in dried blood spots from Nigerian adults in the Federal Capital Territory before policy enforcement, establish baseline levels for future evaluations, assess subgroup variations by demographic and socioeconomic factors, and compare TFA levels with data from 30 countries worldwide.

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Background: Excess dietary sodium is a leading cause of death and disability globally. Because packaged foods are a major source of sodium in many countries, including Australia, mandatory limits for sodium might improve population health. We aimed to estimate the long-term health and economic effect of mandating such thresholds in Australia.

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Background: Excess dietary sodium intake has been associated with death and disability. WHO has released global sodium benchmarks for packaged foods to support countries to reduce population sodium intake. This study aimed to assess the potential health effect, costs, and cost effectiveness of implementing these WHO sodium benchmarks in India.

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Article Synopsis
  • The study investigates the relationship between different types of n-6 polyunsaturated fatty acids (PUFAs), especially linoleic acid (LA), and mortality rates from various causes in a large UK Biobank cohort of over 257,000 individuals.
  • Findings indicate that higher levels of LA are linked to reduced total mortality risk, while higher levels of non-LA n-6 PUFAs are associated with increased mortality risk, particularly from non-cardiovascular and non-cancer causes.
  • The research emphasizes that LA and non-LA n-6 PUFAs should not be treated the same when evaluating health impacts, highlighting the importance of maintaining or increasing LA intake for better health outcomes.
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Article Synopsis
  • - Nigeria aims to limit industrial trans fatty acids (iTFA) in food to improve public health, specifically targeting ischaemic heart disease (IHD), but the impact and costs are unclear.
  • - Using Markov cohort models, researchers estimated that a mandatory iTFA limit would prevent nearly 10,000 IHD deaths and save around $90 million in healthcare costs over the first decade.
  • - The analysis suggests that implementing this policy is cost-effective and could lead to significant health benefits, supporting the idea of regulating iTFAs as a beneficial health strategy for Nigeria.
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