Covalent-fragment screening identifies selective inhibitors of multiple Staphylococcus aureus serine hydrolases important for growth and biofilm formation.

is a leading cause of bacteria-associated mortality worldwide. This is largely because infection sites are often difficult to localize and the bacteria forms biofilms which are not effectively cleared using classical antibiotics. Therefore, there is a need for new tools to both image and treat infections.

Corrigendum to "Antihypertensive medication classes and risk of incident dementia in primary care patients: a longitudinal cohort study in the Netherlands" [The Lancet Regional Health-Europe, Volume 42, July 2024, 100927].

[This corrects the article DOI: 10.1016/j.lanepe.

The impact of MIND diet consumption and physical activity on cognitive functioning in healthy aging older adults.

Modifiable lifestyle factors evidence great promise in reducing cognitive decline in older adults. Greater consumption to the MIND diet (Morris et al.) and increased daily physical activity (Buchman et al.

Action on elevated natriuretic peptide in primary care: a retrospective cohort study.

Background: Natriuretic peptides (NPs) are released by increased ventricular wall stress, most often caused by heart failure (HF). NP level measurement helps select patients clinically suspected of HF who need echocardiography. Yet, the diagnostic actions following NP testing in daily primary care are poorly studied.

Sex differences and trends in managing cardiovascular risk factors in primary care: a dynamic cohort study.

Background: Treatment targets for cardiovascular risk management make no distinction between women and men.

Aim: To explore sex differences in achieving treatment targets in patients that participated in a nurse-led, integrated CVRM care programme in primary care between 2013 and 2019.

Design & Setting: We conducted a dynamic cohort study in the Eindhoven region, south-east of The Netherlands METHOD: We assessed outcomes of three biological risk factors (systolic blood pressure, low density lipoprotein-cholesterol and estimated glomerular filtration rate) and four lifestyle factors (smoking, physical activity, alcohol intake and body mass index).