Assessing Standardisation in Platelet-Rich Plasma (PRP) Injections for the Management of Greater Trochanteric Pain Syndrome (GTPS): A Systematic Review of the Available Literature.

Greater trochanteric pain syndrome (GTPS) is a prevalent musculoskeletal condition characterised by lateral hip pain and reduced function. Platelet-rich plasma (PRP) injections have gained attention as a potential treatment due to their regenerative properties. However, variability in PRP preparation methods and insufficient standardisation in the literature complicate the evaluation of its efficacy and reproducibility.

Synthetic approaches for novel fused pyrimidine derivatives: Design, structural characterization, antiviral, antitumor, and molecular docking evaluation.

The goal of this work was to synthesize new compounds for anticancer evaluation as a trial to obtain new antitumor agents with higher activity and fewer side effects. Therefore, the precursor 2,2'-(1,4-phenylenebis (thiazole-4,2-diyl))bis (3-(dimethylamino)acrylonitrile) was used to synthesize various azolopyrimidine derivatives connected to the thiazole moiety. Compounds -, including pyrazolopyrimidine, triazolopyrimidine, and others, were produced by reacting enaminonitrile with different -nucleophiles.

pH induced structural and conformational changes in nucleocapsid protein leads to intermediate like conformation: a biophysical and computational approach.

Nucleocapsid protein (N) of SARS-CoV-2 is a multivalent protein, which is responsible for viral replication, assembly, packaging and modulates host immune response. In this study, we report conformational measurements of N protein at different pH by observing transition in secondary and tertiary structural contents by biophysical and computational approaches. Spectroscopic measurements revealed that N protein loses its secondary and tertiary structure at extreme acidic pH while maintaining its native conformation at mild acidic and alkaline pH.

An assessment of the knowledge, perception, and willingness to use telepharmacy services among the general public in Riyadh.

The studies concerning Saudis' perceptions and awareness of telepharmacy, as well as their readiness to use this service, are critical for policymakers to devise measures to increase the acceptability of telepharmacy. The present study aimed to assess their knowledge, perceptions, and willingness to use telepharmacy services in Riyadh. The present study was a cross-sectional survey conducted between March 2024 and June 2024.

Hospitalisation patterns for respiratory diseases in Australia: an ecological study.

Objectives: The objective of this study is to examine the hospitalisation profile for respiratory diseases in Australia between 1998 and 2019.

Design: An ecological study.

Setting: A population study that involved all private and public hospitalisations for respiratory diseases in Australia from 1998 to 2019.