Early Attachment Disruption Increases Central Sensitivity of Depressive-Like Behavior to Stimulation by PGE-2.

Early disruption of filial attachment appears to sensitize underlying threat-related processes to produce vulnerability for developing depression when encountering stressors later in life. Evidence indicates neuroinflammatory signaling mediates this effect, though exact mechanisms are poorly understood. In a guinea pig model, early periods of isolation from the mother produce depressive-like behavior and fever, which sensitize with repeated isolation.

A composite F-FDG PET/CT and HER2 tissue-based biomarker to predict response to neoadjuvant pertuzumab and trastuzumab in HER2-positive breast cancer (TBCRC026).

Background: Early metabolic change on PET/CT was predictive of response to neoadjuvant trastuzumab/pertuzumab (HP) in TBCRC026. We hypothesized that a composite biomarker incorporating PET/CT and HER2 tissue-based biomarkers could improve biomarker performance.

Methods: 83 patients with estrogen receptor-negative/HER2-positive breast cancer received neoadjuvant HP alone [pathologic complete response (pCR) 22 %].

Confirmation and characterisation of ALS inhibitor resistant Poa trivialis from Ireland.

Relying on one broad-spectrum product to control grass weeds has resulted in cases of resistance to acetolactate synthase (ALS) inhibitors in species that were not the primary target such as Poa trivialis (POATR), in wheat fields in Ireland. In this study, we have characterised ALS inhibitor resistance in two populations of POATR-R, suspected of being resistant, to (i) sulfonylurea (SUs)-mesosulfuron + iodosulfuron (the selecting agent), (ii) SU + sulfonylamino‑carbonyl-triazolinone (SCT)-mesosulfuron + propoxycarbazone, and (iii) triazolopyrimidine (TP)-pyroxsulam ALS chemistries. Resistant POATR-R populations showed ALS inhibitor cross-resistance associated with target-site resistance (TSR) mutations.

Case Report: Intravascular Lithotripsy of Calcified Iliac Artery Disease to Facilitate Kidney Transplantation.

Intravascular lithotripsy is a novel technique that treats calcified atherosclerotic disease using shock waves to disrupt the rigid plaque. It is an evolving technique with high reported success rates and minimal complications. Calcified plaque in the aorto-iliac arteries is highly prevalent in patients with renal impairment and is a major barrier to kidney transplantation.

Workplace supports for early pregnancy loss: A scoping review of international literature.

Background: Despite the prevalence and impacts of pregnancy loss, there is a lack of statutory or workplace-based supports for workers experiencing pregnancy loss, especially before the point of viability. As reproductive and working ages overlap, workplaces can play a significant role in pregnancy loss experiences.

Objective: The aim of this study is to map the available literature on workplace supports for pregnancy loss before viability.