Publications by authors named "M H Frost"
Bone mineral density and the risk of kidney disease in patients with type 1 diabetes.
J Diabetes Complications
December 2024
Aim: To explore the association between bone disorder and the risk for progression of diabetic kidney disease (DKD) in persons with type 1 diabetes mellitus (T1DM).
Methods: In this prospective cohort study the association between bone mineral density (BMD), bone-derived factors (sclerostin, Dickkopf-1, and osteoprotegerin (OPG)), and four outcomes were investigated: 1) progression of albuminuria; 2) decline in estimated glomerular filtration rate (eGFR) ≥30 %; 3) kidney failure (KF); and 4) a composite kidney outcome consisting of at least one of the outcomes.
Results: In 318 participants (median follow-up time 5.
Article Synopsis
- Individuals with type 1 diabetes (T1D) have an increased risk of fractures, prompting the American Diabetes Association to incorporate bone health assessments into their 2024 Standards of Care.
- A study compared bone mechanical properties and microstructure between 111 individuals with T1D and 37 healthy controls using various imaging techniques to assess bone health.
- Results showed no significant difference in bone mineral density (BMD) between the T1D and control groups, indicating that further research is needed to establish a distinct bone health profile for those with T1D.
Background: NF1 inactivation is associated with sensitivity to MEK inhibitor targeted therapy in low-grade and some high-grade gliomas. NF1 loss may also be a harbinger of exploitable vulnerabilities in IDH-wildtype glioblastoma (GBM). Accurate and consistent detection of NF1 loss, however, is fraught given the large gene size, challenges with complete coverage and variant calling upon sequencing, and mechanisms of mRNA and protein regulation that result in early degradation in the absence of genomic alterations.
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- - The high pathogenicity avian influenza virus H5N1 outbreak highlights the serious threats posed by viral incursions to both wildlife and domestic animals.
- - Recent findings in Australia identified two low pathogenicity avian influenza virus subtypes, H4 and H10, with different evolutionary patterns, emphasizing the complex nature of viral spread.
- - Phylogenetic analysis shows H4 viruses from shorebirds are a new introduction from Asia, while H10 has evolved into a new lineage in various bird populations, illustrating the importance of understanding these dynamics for better disease management.