Publications by authors named "M H F Kox"
One in five deaths worldwide is associated with sepsis, which is defined as organ dysfunction caused by a dysregulated host response to infection. An increased understanding of the pathophysiology of sepsis could provide improved approaches for early detection and treatment. Here we describe the development and validation of a mechanistic mathematical model of the inflammatory response, making use of a combination of in vitro and human in vivo data obtained from experiments where bacterial lipopolysaccharide (LPS) was used to induce an inflammatory response.
View Article and Find Full Text PDFBackground: Respiratory dysfunction is an important contributor to morbidity and mortality in advanced Parkinson's disease (PD), but it is unclear what parameters are sensitive to diagnose and monitor respiratory dysfunction across disease phases.
Objectives: We aimed to characterize respiratory dysfunction in mild to moderate PD.
Methods: In 20 individuals without cardiopulmonary comorbidity, pulmonary and inspiratory muscle function testing were performed ON-medication.
Article Synopsis
- Colorectal surgery often leads to significant postoperative complications, mainly infections, potentially due to monocyte epigenetic changes and immune tolerance.
- A study involving 100 patients measured changes in damage-associated molecular patterns (DAMPs) and cytokine production, alongside exploratory analyses of proteins and DNA accessibility in monocytes.
- Results showed significant increases in plasma DAMPs, particularly HMGB1 and mitochondrial DNA post-surgery, while in vitro tests revealed that HSP70 and HMGB1 reduced the cytokine production capacity of immune cells.
Purpose: Disease heterogeneity in coronavirus disease 2019 (COVID-19) may render the current one-size-fits-all treatment approach suboptimal. We aimed to identify and immunologically characterize clinical phenotypes among critically ill COVID-19 patients, and to assess heterogeneity of corticosteroid treatment effect.
Methods: We applied consensus k-means clustering on 21 clinical parameters obtained within 24 h after admission to the intensive care unit (ICU) from 13,279 COVID-19 patients admitted to 82 Dutch ICUs from February 2020 to February 2022.