Publications by authors named "M H Delfau"
Axicabtagene ciloleucel (axi-cel) demonstrated superior efficacy compared to standard of care as second-line therapy in patients with high-risk relapsed/refractory (R/R) large B cell lymphoma (LBCL) considered eligible for autologous stem cell transplantation (ASCT); however, in clinical practice, roughly half of patients with R/R LBCL are deemed unsuitable candidates for ASCT. The efficacy of axi-cel remains to be ascertained in transplant-ineligible patients. ALYCANTE, an open-label, phase 2 study, evaluated axi-cel as a second-line therapy in 62 patients with R/R LBCL who were considered ineligible for ASCT.
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- Mycosis fungoides (MF) and primary cutaneous CD30-positive T-cell lymphoproliferative disorders (CD30LPD) are common skin lymphomas, and the study aimed to investigate T-cell antigens and PD-1 expression across a large sample of these conditions.
- The research involved analyzing 160 samples from patients, finding that CD7 was the most frequently lost antigen, especially in MF and CD30LPD, while benign inflammatory dermatoses showed no significant T-cell antigen loss.
- The study recommends using CD7 alongside other antigen markers like CD3, CD4, and CD8 for diagnosing MF, and suggests employing double staining techniques for more complex cases.
Primary Cutaneous CD4+ Small/Medium T-Cell Lymphoproliferative Disorders: A Clinical, Pathologic, and Molecular Study of 60 Cases Presenting With a Single Lesion: A Multicenter Study of the French Cutaneous Lymphoma Study Group.
Fanny Beltzung Nicolas Ortonne Laura Pelletier Marie Beylot-Barry Saskia Ingen-Housz-Oro Marie-Hélène Delfau
Am J Surg Pathol
July 2020
Article Synopsis
- Primary cutaneous CD4 small/medium T-cell lymphoproliferative disorder (PCSMLPD) is a newly identified condition classified by the WHO in 2017, characterized by a slow-growing, localized skin lesion primarily in adults (mean age 59).
- In a study of 60 patients, the majority presented with nodules on the head and neck, and 31.9% experienced spontaneous regression, indicating a generally indolent disease course over an average follow-up of 16.6 months.
- Histologically, PCSMLPD often shows extensive nodular or diffuse infiltrates in the dermis and varying patterns of T-follicular helper lineage markers, but commonly