A multidonor class of highly glycan-dependent HIV-1 gp120-gp41 interface-targeting broadly neutralizing antibodies.

Antibodies that target the gp120-gp41 interface of the HIV-1 envelope (Env) trimer comprise a commonly elicited category of broadly neutralizing antibodies (bNAbs). Here, we isolate and characterize VRC44, a bNAb lineage with up to 52% neutralization breadth. The cryoelectron microscopy (cryo-EM) structure of antibody VRC44.

A nomenclatural review of family-group names in the Tettigoniidae (Orthoptera: Ensifera).

The Tettigoniidae is the largest and most complex family within the Orthoptera, and perhaps expectedly, its systematic arrangement is largely unsatisfactory. Recent phylogenetic studies within the group have been almost wholly at odds with traditional morphological classification, and it is clear that a great number of changes will be made to the family in the near future. To remove the element of nomenclatural uncertainty that will inevitably arise with such dramatic changes, I here provide a complete annotated list of all family-group names proposed within the Tettigoniidae in explicit order of priority.

Modeling the acute mucosal toxicity to fractionated radiotherapy combined with the ATM inhibitor WSD0628.

ATM inhibitors are being developed as radiosensitizers to improve the antitumor effects of radiotherapy, but ATM inhibition can also radiosensitize normal tissues. Therefore, understanding the elevated risk for normal tissue toxicities is critical for radiosensitizer development. This study focused on modeling the relationship between acute mucosal toxicity, radiation dose, fractionation schedule, and radiosensitizer exposure.