Background: Diffusion-weighted imaging (DWI), a quantitative magnetic resonance imaging (qMRI) technique, has the potential to aid in disease characterization and treatment response monitoring. MR-Linacs (MRLs) enable simultaneous DWI acquisitions during radiotherapy, uniquely aiding in the collection of large-scale datasets for imaging biomarkers, such as the DWI-derived apparent diffusion coefficient (ADC), without additional patient burden. However, the limited data reporting on variability in MRL scanner performance characteristics, and a lack of established clinical trial quality assurance (QA) procedures, are barriers to this route for biomarker validation.
View Article and Find Full Text PDFObjective Craniofacial abnormalities require intensive surgical interventions associated with major risks. This study aimed to analyze how craniofacial surgical outcomes have changed over recent years. Design This was a retrospective, cross-sectional study.
View Article and Find Full Text PDFEukaryotic initiation factor 4E (eIF4E) serves as a regulatory hub for oncogene-driven protein synthesis and is considered a promising anticancer target. Here we screen a fragment library against eIF4E and identify a ligand-binding site with previously unknown function. Follow-up structure-based design yields a low nM tool compound (4, K = 0.
View Article and Find Full Text PDFVascular rings are rare congenital defects that can cause tracheal and/or esophageal compression. Prenatal detection is increasing due to advances in screening and fetal echocardiography. Postnatal outcomes remain variable.
View Article and Find Full Text PDFIntroduction: Despite the surge in Anterior Cervical Discectomy and Fusion (ACDF) and Posterior Cervical Decompression and Fusion (PCDF) procedures over the past two decades, there remains a paucity of data on their comparative costs in geriatric patients with cervical disc herniation. This study provides a comprehensive cost analysis of ACDF and PCDF in this patient population.
Methods: A total of 282 geriatric patients who underwent ACDF or PCDF for cervical disc herniation over a 12-year period were analyzed to assess total surgical costs, including pre-operative, procedural, and post-operative expenses.