Comparison of ChatGPT-4, Copilot, Bard and Gemini Ultra on an Otolaryngology Question Bank.

Objective: To compare the performance of Google Bard, Microsoft Copilot, GPT-4 with vision (GPT-4) and Gemini Ultra on the OTO Chautauqua, a student-created, faculty-reviewed otolaryngology question bank.

Study Design: Comparative performance evaluation of different LLMs.

Setting: N/A.

Quantifying multi-institutional ADC measurement variability of 1.5 T MR-Linacs: A phantom and in vivo study.

Background: Diffusion-weighted imaging (DWI), a quantitative magnetic resonance imaging (qMRI) technique, has the potential to aid in disease characterization and treatment response monitoring. MR-Linacs (MRLs) enable simultaneous DWI acquisitions during radiotherapy, uniquely aiding in the collection of large-scale datasets for imaging biomarkers, such as the DWI-derived apparent diffusion coefficient (ADC), without additional patient burden. However, the limited data reporting on variability in MRL scanner performance characteristics, and a lack of established clinical trial quality assurance (QA) procedures, are barriers to this route for biomarker validation.

Complications After Craniofacial Surgery: A Review From 2012 to 2020.

Objective Craniofacial abnormalities require intensive surgical interventions associated with major risks. This study aimed to analyze how craniofacial surgical outcomes have changed over recent years. Design This was a retrospective, cross-sectional study.

Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function.

Eukaryotic initiation factor 4E (eIF4E) serves as a regulatory hub for oncogene-driven protein synthesis and is considered a promising anticancer target. Here we screen a fragment library against eIF4E and identify a ligand-binding site with previously unknown function. Follow-up structure-based design yields a low nM tool compound (4, K = 0.

Postnatal Outcomes in Prenatally Detected Vascular Rings.

Vascular rings are rare congenital defects that can cause tracheal and/or esophageal compression. Prenatal detection is increasing due to advances in screening and fetal echocardiography. Postnatal outcomes remain variable.