Multi-Omics Assessment of Puff Volume-Mediated Salivary Biomarkers of Metal Exposure and Oxidative Injury Associated with Electronic Nicotine Delivery Systems.

Background: Since their inception, electronic nicotine delivery systems (ENDS) have gained increasing popularity, sparking a vaping epidemic among adolescents in the US and globally. Several ENDS safety concerns have emerged as device features and formats that contribute to heavy metal exposure and toxicity continue to evolve and outpace regulatory efforts.

Objectives: Our objective was to integrate ENDS emission profiles with salivary proteome and metabolome data to characterize exposure factors that may influence adverse vaping-mediated health outcomes.

Ketone monoester ingestion improves cardiac function in adults with type 2 diabetes: a double-blind, placebo controlled, randomised, crossover trial.

Type 2 diabetes (T2D) is a metabolic disease associated with cardiovascular dysfunction. The myocardium preferentially uses ketones over free fatty acids as a more energy efficient substrate. The primary aim was to assess the effects of ketone monoester (K) ingestion on cardiac output index ().

Costs of Overly Broad Recalls.

Overly broad recalls following an FDA advisory occur when the source of an outbreak is originally misidentified or cannot be promptly identified. In this situation, an entire product category might be recalled (e.g.

T Clusters Are More Sensitive Than Mean T Change to Detect Early and Longitudinal Changes in Anterior Cruciate Ligament Reconstructed and Healthy Knees.

Background: Post-traumatic osteoarthritis (PTOA) often follows anterior cruciate ligament reconstruction (ACLR), leading to early cartilage degradation. Change in mean T fails to capture subject-specific spatial-temporal variations, highlighting the need for robust quantitative methods for early PTOA detection and monitoring.

Purpose/hypothesis: Develop and apply 3D T cluster analysis to ACLR and healthy knees over 2.