Design, synthesis and biological evaluation of 2-substituted-6-[(4-substituted-1-piperidyl)methyl]-1H-benzimidazoles as inhibitors of ebola virus infection.

Novel 2-substituted-6-[(4-substituted-1-piperidyl)methyl]-1H-benzimidazoles were designed and synthesized as Ebola virus inhibitors. The proposed structures of the new prepared benzimidazole-piperidine hybrids were confirmed based on their spectral data and CHN analyses. The target compounds were screened in vitro for their anti-Ebola activity.

Highly convergent synthesis and antiviral activity of (E)-but-2-enyl nucleoside phosphonoamidates.

Several hitherto unknown (E)-but-2-enyl nucleoside phosphonoamidate analogs (ANPs) were prepared directed with nitrogen reagents by cross-metathesis in water-under ultrasound irradiation. Two diastereoisomers were formally identified by X-ray diffraction. These compounds were evaluated against a large spectrum of DNA and RNA viruses.

Mechanistic Investigation of a Dual Bicyclic Photoinitiating System for Synthesis of Organic-Inorganic Hybrid Materials.

One-pot synthesis of organic-inorganic hybrid materials under light requires specific photoinitiating systems which are able to release several different initiating species after light absorption. In this paper, the reaction mechanism of a photocyclic three-component initiating system based on isopropylthioxanthone as photoinitiator and an iodonium salt and a thiol as co-initiators was studied. It is shown that this system enables simultaneous release of both radicals and protons which are able to initiate a free radical photopolymerization and the hydrolysis-condensation of a sol-gel network, respectively.

Recent progress for the synthesis of selected carbocyclic nucleosides.

Nucleoside analogs are extremely useful for the development of therapeutic agents to control viral diseases and cancer. Among the numerous modifications on the nucleoside skeleton, replacement of the oxygen of the furanose ring by a CH2 group resulted in increased flexibility and higher resistance to phosphorylases and led to carbocyclic nucleoside analogs (or carbanucleosides). The broad spectrum of biological activities of carbocyclic nucleosides led to tremendous research interest in their syntheses.