Publications by authors named "M H Bentz"
The HIV integrase inhibitor, dolutegravir (DTG), in the absence of eliciting integrase (int) resistance, has been reported to select mutations in the virus 3'-polypurine tract (3'-PPT) adjacent to the 3'-LTR U3. An analog of DTG, cabotegravir (CAB), has a high genetic barrier to drug resistance and is used in formulations for treatment and long-acting pre-exposure prophylaxis. We examined whether mutations observed for DTG would emerge in vitro with CAB.
View Article and Find Full Text PDFThis report describes the complete genome sequence assemblies from four representative isolates of the human pathogen . These data provide necessary references to aid accurate sequence-based species discrimination among closely related spp. pathogens.
View Article and Find Full Text PDFArticle Synopsis
- The CDC's research revealed a rise in serotype 4 invasive pneumococcal disease (IPD) cases, especially among adults experiencing homelessness between 2016-2022.
- An analysis of IPD isolates identified a new serotype 4 variant created through genetic recombination between two parental strains, occurring mainly in Oregon.
- The increase in serotype 4 cases, highlighting transmission among adults living in homelessness, may indicate a concerning trend in bacterial evolution and disease spread.
Article Synopsis
- The BK polyomavirus (BKPyV) typically causes no symptoms in healthy adults but can lead to serious health issues like nephropathies and hemorrhagic cystitis in immunocompromised patients, particularly those with organ transplants.
- Recent research shows that BKPyV can use extracellular vesicles to move between cells without causing cell damage, which is a unique strategy for virus entry and exit.
- The study looked into whether BKPyV uses certain viral protein domains to assist in this vesicle trafficking, finding that while a specific domain in the VP1 protein doesn't aid in vesicle association, it's critical for proper viral particle assembly.