Publications by authors named "M H Bemanian"
Safety of 1 mcg/mL as the starting dose in cluster protocol for hymenoptera immunotherapy.
Allergol Immunopathol (Madr)
January 2025
Background: Hymenoptera venom allergy is a potentially severe allergic reaction in the general population. The only preventative approach in these cases is venom immunotherapy (VIT), which follows different protocols. The recommended initial dose is 0.
View Article and Find Full Text PDFNoninfectious Complications in B-Lymphopenic Common Variable Immunodeficiency.
J Investig Allergol Clin Immunol
July 2024
Article Synopsis
- Common variable immunodeficiency (CVID) is a significant disorder characterized by both infectious and noninfectious complications, with 66.4% of patients experiencing noninfectious issues such as enteropathy and autoimmunity.
- In a study of 387 CVID patients, those with B-cell lymphopenia showed higher rates of certain complications, particularly in the dermatologic, endocrine, and musculoskeletal systems.
- The study highlights the need for routine monitoring and appropriate treatment strategies, including medication alongside immunoglobulin therapy, to manage complications associated with CVID effectively.
Background: The poly-sensitization to Hymenoptera venom makes it difficult to select genuine allergens for immunotherapy and increases patients' costs. The objective of this study was to determine the culprit allergen in dual or triple-sensitized patients to three Hymenoptera venoms through molecular diagnosis and evaluating the results of incorporating the molecular diagnosis with skin tests.
Methods: Thirty-two patients with anaphylactic reactions and dual or triple-sensitization to Hymenoptera venoms in skin tests entered this study.
Article Synopsis
- The study investigates the safety of a single-step sensitization test for Hymenoptera venom, aiming to improve diagnostic measures for anaphylaxis due to insect stings.
- Conducted in Golestan province, Iran, the study involved 33 patients who received a skin test using undiluted venom extracts from three types of stinging insects.
- Results indicated a low incidence of allergic reactions, with most patients showing negative skin test results and only minor skin reactions that resolved quickly, suggesting the approach is safe.
Background: Chronic Rhinosinusitis (CRS) is a paranasal sinus inflammatory disease and is divided into two subgroups defined as CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). CRSwNP displays a T helper (Th)2 biased phenotype, and based on sensitivity or tolerance to aspirin or non-steroidal anti-inflammatory drugs (NSAID), is further subdivided into Aspirin-exacerbated respiratory disease (AERD) and non-AERD groups. Considering the challenge of diagnosis and treatment in patients with CRSwNP, particularly the AERD subtype, and the significance of endotyping in these patients, we examined the immune profile and endotyping based on gene expression analysis in the AERD and the non-AERD groups of patients with CRSwNP.
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