Publications by authors named "M H Becquemin"

Nebulization is a drug delivery mode whose prescription and application remain uncertain. A guide to good practice has been proposed by the work group on aerosol therapy of the French Society for Respiratory Diseases, so-called GAT. The previous recommendations date from 2007.

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Article Synopsis
  • - The study aimed to compare the effects of different diluent volumes (6 mL vs. 12 mL) on aerosol characteristics and pharmacokinetics of nebulized colistimethate sodium (CMS) for treating ventilator-associated pneumonia caused by multidrug-resistant (MDR) bacteria.
  • - Results showed that the 6 mL diluent led to smaller aerosol particle sizes and shorter nebulization times, while pharmacokinetic measures in plasma and urine remained similar across both diluent volumes.
  • - The study concluded that using 6 mL for CMS dilution improves nebulization efficiency and stability without negatively affecting drug delivery or absorption in the body.
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In previous studies of the smoke from regular cigarettes and water pipes, we measured aerosol particle sizes in three streams; S1, inhaled by the smoker, S2, released by the device itself and S3, exhaled by the smoker. We used an electrostatic low-pressure impactor (ELPI), giving particle size distributions in real time and calculated median diameters, D50, and dispersion (σg). This allowed us to predict airway deposition.

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Marketed since 2004 as an alternative to nicotine delivery and advertised as a valid means to smoking cessation, the electronic (e)-cigarette has been the subject of much controversy but very little experimental study. This review provides a brief summary of the current knowledge of this product. Propylene glycol and glycerol, the main ingredients of the fluid that is vaporized, have proved to be harmless in the fog machines of the entertainment industry.

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