Publications by authors named "M H Abumaree"
Article Synopsis
- The study investigated how different concentrations of interleukin 1 beta (IL-1β) affect the behavior of human bone marrow mesenchymal stem cells (hBM-MSCs) in terms of adhesion, proliferation, and migration.
- Results showed that low concentrations of IL-1β (up to 50 ng/ml) enhanced cell growth and movement, while higher concentrations (100 ng/ml) significantly reduced these activities.
- The study highlights that IL-1β stimulation increases the expression of essential genes related to MSC function, potentially improving their ability to respond to injury in inflamed environments.
We studied the potential of human bone marrow-derived mesenchymal stem cell conditioned media (hBMSC CM) in protecting endothelial cell properties (viability, proliferation, and migrations) from the deleterious effects produced by the inflammatory environment of HO. Additionally, we investigated their impact on the endothelial cells' gene expression of some inflammatory-related genes, namely, TGF-1, FOS, ATF3, RAF-1, and SMAD3. Human umbilical vein endothelial cells (HUVECs) were cultured individually under three conditions: alone, with varying concentrations of HO, or with varying concentrations of HO and hBMSC CM.
View Article and Find Full Text PDFPreeclampsia (PE) is a serious medically important disorder of human pregnancy, which features pregnancy-induced hypertension and proteinuria. The severe form of PE can progress to eclampsia, a convulsive, life-threatening condition. When placental growth and perfusion are abnormal, the placenta experiences oxidative stress and subsequently secretes abnormal amounts of certain pro-angiogenic factors (eg, PlGF) as well as anti-angiogenic factors (eg, sFlt-1) that enter the maternal circulation.
View Article and Find Full Text PDFMesenchymal stem cells (MSCs) have been shown to suppress tumor growth, inhibit angiogenesis, regulate cellular signaling, and induce apoptosis in cancer cells. We have earlier reported that placenta-derived decidua parietalis mesenchymal stem/stromal cells (DPMSCs) not only retained their functional characteristics in the cancer microenvironment but also exhibited increased expression of anti-apoptotic genes, demonstrating their anti-tumor properties in the tumor setting. In this study, we have further evaluated the effects of DPMSCs on the functional outcome of human breast cancer cell line MDA231.
View Article and Find Full Text PDFIntroduction: Human decidua basalis mesenchymal stem cells (DBMSCs) are potential therapeutics for the medication to cure inflammatory diseases, like atherosclerosis. The current study investigates the capacity of DBMSCs to stay alive and function in a harmful inflammatory environment induced by high levels of lipopolysaccharide (LPS).
Methods: DBMSCs were exposed to different levels of LPS, and their viability and functional responses (proliferation, adhesion, and migration) were examined.