Publications by authors named "M H Abdelhamed"
Ulcerative colitis (UC) is a debilitating chronic disease marked by persistent inflammation and intestinal fibrosis. Despite the availability of various treatments, many patients fail to achieve long-term remission, underscoring a significant unmet therapeutic need. BMS-477118, a reversible inhibitor of dipeptidyl peptidase 4 (DPP4), has demonstrated anti-inflammatory properties in preclinical and clinical studies with minimal adverse effects compared to other antidiabetic agents.
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- Liver fibrosis poses a major health issue worldwide and can lead to severe conditions like cirrhosis and liver cancer, with the hedgehog signaling pathway playing a crucial role in its progression, making its inhibitors potential treatment options.
- The study tested two drugs, simvastatin and STA-9090, individually and together in rats with induced liver damage, assessing their effects on liver health and the hedgehog pathway.
- Results showed that while both drugs improved liver conditions, their combination offered even greater benefits, including better survival rates and healthier liver tissue, suggesting a promising approach for future clinical treatments.
Background: Colorectal cancer is the 3rd most common cancer worldwide, representing 10% of all cancer types, and is considered the 2nd leading cause of cancer-related deaths. It usually metastasizes to the liver or lung. Para-aortic lymph node metastasis is considered a metastatic disease (stage 4) according to the AJCC and is considered a regional disease (stage 3) according to the JSCCR.
View Article and Find Full Text PDFAberrant activation of the NLRP3 inflammasome is recognized to induce a chronic inflammatory response in the liver, ultimately leading to hepatic fibrosis. HSP90 is suggested to regulate NLRP3 activation and its downstream signaling. This study is the first to explore the potential therapeutic role of pimitespib in mitigating liver fibrosis in rats.
View Article and Find Full Text PDFBackground: Cognitive dysfunction may be one of the hazardous late effects among survivors of pediatric hematological malignancies. Our study aimed to explore cognitive performance and assess the global and regional brain volume changes in survivors of hematological malignancies.
Methods: This case-control study was conducted on 68 survivors of hematological malignancies, with a median follow-up period of 2 years (ranging from 1 to 6.