Publications by authors named "M H Abdel-Hamid"
Introduction: Pontocerebellar hypoplasia (PCH) represents a group of rare disorders with prenatal onset and time-dependent loss of brain parenchyma, predominantly affecting the cerebellum and pons with variable involvement of supratentorial structures. Radiologically and pathologically, they are characterized by small cerebellum and pons. Our study aimed to screen for the gene variants in Egyptian patients with PCH for proper counseling and to describe the brain MRI and the clinical phenotype and compare, them to those described in the literature.
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- The study focuses on developing green silver nanoparticles (AgNPs) to combat multidrug-resistant MRSA strains, which are a growing threat in healthcare settings, by examining their bactericidal properties and effect on biofilm formation.
- Researchers synthesized new AgNPs from plant extracts and tested their effectiveness against a newly identified MRSA strain (RM-Ph8), revealing that these nanoparticles could destroy the bacteria and inhibit biofilm formation.
- Results showed that phyto-AgNPs not only effectively killed MRSA but also improved liver and kidney function in infected rats, enhancing immune responses significantly, making them a potential new treatment for MRSA infections.
Background: The population structure of the malaria parasite Plasmodium falciparum can reveal underlying adaptive evolutionary processes. Selective pressures to maintain complex genetic backgrounds can encourage inbreeding, producing distinct parasite clusters identifiable by population structure analyses.
Methods: We analysed population structure in 3783 P falciparum genomes from 21 countries across Africa, provided by the MalariaGEN Pf7 dataset.
We identified two homozygous truncating variants in GON4L [NM_001282860.2:c.62_63del, p.
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- Recent findings show biallelic loss of function variants in the ESAM gene linked to prenatal intracranial hemorrhage in 14 individuals across 9 families, including 4 patients from two families with varied clinical presentations.
- Brain imaging revealed different neurological issues such as encephalopathy, seizures, and hydrocephalus, with one patient showing unique symptoms like white matter volume loss and porencephalic cysts.
- Exome sequencing uncovered two new harmful ESAM variants and an additional MC4R variant in one patient, suggesting a connection to obesity and highlighting ESAM's role as a critical gene affecting brain health.