Mendelian randomization (MR) is a technique which uses genetic data to uncover causal relationships between variables. With the growing availability of large-scale biobank data, there is increasing interest in elucidating nuances in these relationships using MR. Stratified MR techniques such as doubly-ranked MR (DRMR) and residual stratification MR have been developed to identify nonlinearity in causal relationships.
View Article and Find Full Text PDFBackground: Maternal mortality is not on track to meet Sustainable Development Goal (SDG) target 3.1 of a global maternal mortality ratio below 70 per 100 000 livebirths by 2030. Updated evidence on causes of death is needed to accelerate progress.
View Article and Find Full Text PDFBackground: Emergency cesarean section (EmCS) is an effective means to save the lives of the mother and fetus. Women who undergo EmCS experience sudden physiological changes and high level of psychological stress response due to its complexity, risks, and urgency. They may consider their delivery as traumatic childbirth.
View Article and Find Full Text PDFInfectious disease superspreading is a phenomenon where few primary cases generate unexpectedly large numbers of secondary cases. Superspreading, is frequently documented in epidemiology literature, and is considered a consequence of heterogeneity in transmission. Since understanding the risks of superspreading became a rising concern from both statistical modelling and public health aspects, the R package modelSSE provides comprehensive analytical tools to characterize transmission heterogeneity.
View Article and Find Full Text PDFObjective: Despite the prevalence of depressive disorders among youth, there is no health system model to address the prevention of these disorders.
Method: With the goal of creating effective, tolerable, and scalable interventions for the prevention of adolescent depression, we have fielded three randomized clinical trials, centered in health care delivery organizations that use a whole-of-society approach: (a) Path 2 Purpose ( = 664), comparing the Competent Adulthood Transition with Cognitive Behavioral, Humanistic, and Interpersonal Training (CATCH-IT; B. W.