Publications by authors named "M Gupte"
Background: Enteric infections are hypothesized to be associated with intussusception in children. A small increase in intussusception following rotavirus vaccination has been seen in some settings. We conducted post-marketing surveillance for intussusception following rotavirus vaccine, Rotavac introduction in India and evaluated association of intussusception with enteric pathogens.
View Article and Find Full Text PDFGlycogen synthase kinase 3 (GSK-3), a serine-threonine kinase with two isoforms (α and β) is implicated in the pathogenesis of type 2 diabetes mellitus (T2D). Recently, we reported the isoform-specific role of GSK-3 in T2D using homozygous GSK-3α/β knockout mice. Although the homozygous inhibition models are idealistic in a preclinical setting, they do not mimic the inhibition seen with pharmacological agents.
View Article and Find Full Text PDFSeveral hepatitis A outbreaks have recently been reported in Kerala state, India. To inform coverage decision of hepatitis A vaccine in Kerala, this study aimed to examine the cost-effectiveness of 1) hepatitis A vaccination among children aged 1 year and individuals aged 15 years, and 2) serological screening of individuals aged 15 years and vaccination of susceptible as compared to no vaccination or vaccination without serological screening. Both live attenuated hepatitis A vaccine and inactivated hepatitis A vaccine were considered in the analysis.
View Article and Find Full Text PDFLyme Borreliosis, a public health concern in India: Findings of serosurvey from two states.
Med J Armed Forces India
October 2022
Article Synopsis
- Lyme borreliosis represents a significant public health issue in India, with limited understanding of its prevalence and insufficient data on its epidemiology, prompting a study in Sikkim and Arunachal Pradesh to assess seropositivity.
- The study enrolled 793 participants and utilized the NovaLisa™ Lyme Borrelia IgG ELISA kit for qualitative detection of IgG antibodies, revealing a seroprevalence of 3.7%, with varying rates between the two states (4.1% in Arunachal Pradesh and 2.3% in Sikkim).
- The findings indicate that Sikkim is a newly identified endemic area for Lyme disease, and no direct link was found between Lyme-related symptoms and Ig
Background: Taurodontism is an anomalous developmental condition where the coronal portion of the tooth is enlarged while the radicular portion is compromised. This may have important clinical implications while considering endodontic or exodontic procedures which may affect the technique of the treatment or its prognosis.
Case Report: This article describes the case of a 4-year-old female girl with molars exhibiting taurodontism with its clinical management and a review of this unique clinical condition.