Publications by authors named "M Gunnarsson"
The study objective was to assess the effects of a five-week compassionate mind training for university students regarding symptoms of depression, anxiety and stress, and self-compassion compared with an active control group. Swedish university students were randomized to a compassionate mind training group or to an active control group. The outcome measures were.
View Article and Find Full Text PDFBackground: Surgery remains an important treatment for low-risk patients with severe symptomatic aortic stenosis (AS). We evaluated 5-year outcomes in low-risk patients undergoing isolated surgical aortic valve replacement (SAVR) or SAVR with concomitant procedures within the randomized PARTNER 3 trial.
Methods: In the PARTNER 3 trial, 454 patients underwent surgery for severe, symptomatic, tri-leaflet AS and were followed for 5 years.
Cryogenic probe technology enables multidimensional solid-state NMR of the stratum corneum without isotope labeling.
Solid State Nucl Magn Reson
December 2024
Solid-state NMR has great potential for investigating molecular structure, dynamics, and organization of the stratum corneum, the outer 10-20 μm of the skin, but is hampered by the unfeasibility of isotope labelling as generally required to reach sufficient signal-to-noise ratio for the more informative multidimensional NMR techniques. In this preliminary study of pig stratum corneum at 35 °C and water-free conditions, we demonstrate that cryogenic probe technology offers sufficient signal boost to observe previously undetectable minor resonances that can be uniquely assigned to fluid cholesterol, ceramides, and triacylglycerols, as well as enables H-H spin diffusion monitored by 2D H-C HETCOR to estimate 1-100 nm distances between specific atomic sites on proteins and lipids. The new capabilities open up for future multidimensional solid-state NMR studies to answer long-standing questions about partitioning of additives, such as pharmaceutically active substances, between solid and liquid domains within the protein and lipid phases in the stratum corneum and the lipids of the sebum.
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- This study evaluated the effectiveness and safety of low-dose rituximab compared to standard therapies for treating multiple sclerosis (MS) in a Swedish cohort.
- Over 4,900 participants were analyzed, revealing that rituximab had similar rates of disability progression and MS Impact Scale improvements compared to approved treatments.
- Although rituximab showed lower relapse rates and better treatment adherence, it was linked to a higher risk of infections, particularly when switched from other therapies.
Background: Cardiovascular disease (CVD) is the leading cause of death worldwide, but prevalence estimates in former professional athletes are limited.
Objectives: HUDDLE (Heart Health: Understanding and Diagnosing Disease by Leveraging Echocardiograms) aimed to raise awareness and estimate the prevalence of CVD and associated risk factors among members of the National Football League (NFL) Alumni Association and their families through education and screening events.
Methods: HUDDLE was a multicity, cross-sectional study of NFL alumni and family members aged 50 years and older.